| 摘要: |
| 目的探讨妊娠中晚期妇女25-羟维生素D[25（OH）D]与骨代谢标志物的水平及关系。方法采用电化学发光法检测孕中晚期（13～40周）1090例孕妇和120例体检非妊娠健康妇女25（OH）D、N-端骨钙素（N-MID）、β-胶原特殊序列(β-CTX）。结果妊娠中晚期孕妇25（OH）D平均水平（11.23±5.82）ng/ml，其中25（OH）D水平缺乏、不足、正常分别为917例（84.13%）、152例（13.94%）和21例（1.93%）。冬春季孕妇25（OH）D水平（9.97±5.28）ng/ml低于夏秋季孕妇（12.24±5.77）ng/ml（P＜0.05）。不同年龄组间孕妇血清25（OH）D、N-MID、β-CTX水平差异均有统计学意义（均P＜0.05）。血清25（OH）D水平与N-MID指标无相关（r=-0.017，P＞0.05），与β-CTX指标呈负相关（r＝-0.090，P＜0.05），N-MID与β-CTX间呈正相关（r＝0.586，P＜0.05）。结论妊娠中晚期妇女普遍存在维生素D缺乏现象，冬春季更易出现25（OH）D缺乏，不同年龄段孕妇25（OH）D与骨代谢标志物水平不同，25（OH）D水平与N-MID指标无相关，与β-CTX指标呈负相关，N-MID与β-CTX指标呈正相关性。 |
| 关键词: 妊娠 25- 羟维生素 D N- 端骨钙素 β- 胶原特殊序列 |
| DOI：10.12056/j.issn.1006-2785.2018.40.6.2017-1902 |
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| Relationships of serum 25-hydroxyvitamin D levels with bone metabolism markers in the second and third trimester of pregnant |
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Shool of Laboratory Medicine，Wenzhou Medical University
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| Abstract: |
| Objective To investigate the relationships of serum 25-hydroxyvitamin D levels with bone metabolism markers in the second and third trimester of pregnancy women. Methods A total of 1090 pregnant women(13-40 weeks gestational age) and 120 healthy nulliparous were enrolled . The levels of serum 25 (OH)D, N-MID, β-CTX were determined by electrochemical luminescence. Results The average serum 25 (OH)D level was (11.23 ±5.82)ng/ml in the second and third trimester of pregnancy. There 917 cases (84.13％ ) with 25 (OH)D deficiency, 152 cases (13.94％) with insufficiency and 21 cases (1.93％ ) with sufficiency．The serum 25(OH)D level in winter and spring was lower than that in summer and autumn (9.97±5.28 ng/ml vs. 12.24±5.77 ng/ml, P＜0.05).There were significant differences in serum 25 （OH）D, N-MID and β-CTX levels among pregnant women in different age groups (P＜0.05)．The level of Vitamin D was not correlated with N-MID(r=-0.017, P ＞0.05), negatively correlated with β-CTX (r=-0.090, P＜0.05); and N-MID was positively correlated with β-CTX (r=0.586, P＜0.05). Conclusion Vitamin D deficiency is common during the second and third trimester of pregnant women, particularly in winter and spring seasons. The serum 25(OH)D and N-MID, β-CTX levels are different in pregnant women of different ages. The level of serum 25 (OH)D shows no significant correlation with N-MID but negative correlation with β-CTX. |
| Key words: Pregnant 25-hydroxyvitaminD N-MID β-CTX |
