| 摘要: |
| 目的探讨血清25-羟基维生素D（25-OH-VD）水平、胎盘绒毛膜组织中维生素D受体（VDR）蛋白表达水平与子痫前期的关系，并观察维生素D的干预效果。方法选取200例剖宫产终止妊娠的孕妇为研究对象，其中无妊娠期并发症的正常晚期孕妇80例（对照组），子痫前期孕妇120例（观察组）；观察组又随机分为观察组A（不干预）与观察组B（维生素D干预，诊断为子痫前期后即开始服用维生素D滴剂，600IU/d），各60例。观察并比较3组孕妇血清25-OH-VD水平，胎盘绒毛膜组织中VDR蛋白表达水平，以及观察组A与B的子痫前期分层情况。结果3组孕妇妊娠终止时的血清25-OH-VD水平均高于妊娠20周时的水平（均P＜0.05）；妊娠20周时，对照组血清25-OH-VD水平高于观察组A及B（均P＜0.05），观察组A与B比较差异无统计学意义（P＞0.05）；妊娠终止时，观察组B、对照组血清25-OH-VD水平均高于观察组A（均P＜0.05），对照组与观察组B比较差异无统计学意义（P＞0.05）。观察组B、对照组绒毛膜组织中VDR蛋白表达水平均高于观察组A（均P＜0.05），对照组与观察组B比较差异无统计学意义（P＞0.05）。在妊娠终止时，观察组B进展为重度子痫前期的发生率明显低于观察组A（P＜0.05）。结论补充维生素D有助于提高子痫前期孕妇血清25-OH-VD水平，上调绒毛膜组织中VDR蛋白表达水平，从而减少子痫的发生。 |
| 关键词: 25- 羟基维生素 D 维生素 D 受体 子痫前期 |
| DOI：10.12056/j.issn.1006-2785.2017.39.23.2017-1916 |
| 分类号: |
| 基金项目:温州市科技局计划项目（Y20160345） |
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| Relationship of serum 25-hydroxy-vitamin D level and vitamin D receptor expression in placenta with preeclampsia and intervention effect of vitamin D |
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the Second Affiliated Hospital of Wenzhou Medical University
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| Abstract: |
| Objective To investigate serum levels of 25-hydroxy-vitamin D (25-OH-VD) and expression of vitamin D receptor (VDR) protein in placenta chorion tissue of patients with preeclampsia, and the intervention effect of vitamin D. Methods Two hundred puerperants with cesarean section were enrolled in the study, including 80 cases of normal pregnancy (group C) and 120 cases with preeclampsia (the study group) . The study group was further divided into two groups with 60 cases in each, group A had no vitamin D intervention and group B received vitamin D drops 600IU/d after the diagnosis of preeclampsia. Serum 25-OH-VD levels and the expression of VDR protein in placental chorion tissue were determined and compared among 3 groups. Results Serum 25-OH-VD levels at the termination of pregnancy were higher than those at the 20 week of gestation in
all three groups (P＜0.05). At 20 weeks after pregnancy, the serum 25-OH-VD level of group C was higher than that of groups A
and B (all P＜0.05), there was no significant difference between groups A and B (P ＞0.05). At the termination of pregnancy, the serum 25-OH-VD levels of groups B and C were higher than those of group A (P＜0.05), there was no significant difference between group B and C (P ＞0.05). The expression level of VDR protein in the chorion tissue of groups B and C was higher than that of group A at the termination of pregnancy (P＜0.05), there was no significant difference between group B and C (P ＞ 0.05). The incidence of severe preeclampsia in group B was significantly lower than that in group A (P＜0.05). Conclusion Vitamin D supplementation may improve serum 25-OH-VD levels in preeclampsia women, up-regulate VDR protein expression in chorion tissue, and reduce the occurrence of eclampsia. |
| Key words: 25-hydroxy vitamin D Vitamin D receptor Preeclampsia |
