| 摘要: |
| 目的探讨血清淀粉样蛋白A（SAA）、触珠蛋白（Hp）水平与急性脑梗死患者预后的相关性。方法选择2016年1月至2017年4月收治的急性脑梗死患者601例，检测血清中SAA和Hp水平。采用美国国立卫生研究院卒中量表（NIHSS）评估患者入院2周后预后的严重程度。采用Pearson相关分析研究血清中SAA、Hp水平与急性脑梗死患者2周后预后严重程度的相关性。出院后随访3个月，采用改良Rankin量表（mRS）评估患者3个月预后情况，采用logistic回归分析急性脑梗死患者的预后因素。结果601例急性脑梗死患者中，2周后预后程度轻度组451例，中度组130例，重度组20例。重度组血清SAA、Hp水平[（85.90±64.56）、（1860.00±91.59）mg/L]高于中、轻度组[（31.75±47.39）、（1431.55±89.45）；（18.56±33.60）、（1262.72±82.57）mg/L]，中度组高于轻度组，差异均有统计学意义（F=33.320、4.532，均P＜0.05），血清中SAA、Hp水平与急性脑梗死患者2周后预后严重程度呈正相关（r=0.282、0.137，P＜0.05）；3个月良好预后组490例，不良预后组111例，多因素logistic回归分析显示SAA、年龄是急性脑梗死患者3个月后预后不良的独立危险因素（均P＜0.05），Hp作为急性脑梗死患者3个月预后不良的独立危险因素依据不足（P＞0.05）。结论血清中SAA、Hp水平与急性脑梗死患者预后相关，临床上可通过检测SAA、Hp水平来判断急性脑梗死患者预后情况，SAA水平是急性脑梗死患者预后不良的独立危险因素。 |
| 关键词: 急性脑梗死 血清淀粉样蛋白 A 触珠蛋白 预后 |
| DOI：10.12056/j.issn.1006-2785.2018.40.6.2017-2168 |
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| 基金项目: |
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| Correlation of serum amyloid A （SAA）and haptoglobin levels with prognosis of acute cerebral infarction |
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Hangzhou First People's Hospital
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| Abstract: |
| Objective To investigate the correlation of serum amyloid A (SAA) and hptoglobin levels with the prognosis of
acute cerebral infarction. Methods Six hundred and one patients with acute cerebral infarction admitted in the Department of Neurology, Hangzhou First People's Hospital from January 2016 to April 2017 were enrolled in the study. The levels of SAA and haptoglobin in serum were measured by dual-ray immunoturbidimetry. The National Institutes of Health Stroke Scale(NIHSS) was used to assess the severity of prognosis 2 weeks after admission. Pearson correlation analysis was performed to determine the correlation between serum SAA, haptoglobin levels and the severity of prognosis in patients. All patients were followed up for 3 months after discharge and assessed with a modified Rankin scale (mRS). Univariate analysis and multivariate logistic regression analyses were used to analyze the prognostic factors of acute cerebral infarction for 3 months. Results In 601 patients there were 451 mild cases, 130 moderate cases and 20 severe cases. The levels of serum SAA and haptoglobin in severe group [(85.90±64.56)mg/L and(1 860.00±91.59)mg/L)] were higher than those in moderate [(31.75±47.39)mg/L and(1 431.55±89.45) mg/L]and mild group [(18.56±33.60)mg/L and (1 262.72±82.57)mg/L)] , while the levels in moderate group were higher than
those in mild group [(F=33.320 and 4.532, both P＜0.05)]. Pearson analysis showed that the serum SAA and haptoglobin levels were positively correlated with the severity of the prognosis of acute cerebral infarction after 2 weeks (r = 0.282, r = 0.137, P＜ 0.05). After following up for 3 months, there were 490 patients with good outcome and 111 patients with poor outcome. Multivariate logistic regression analysis showed that SAA and age were independent risk factors for poor outcome of acute cerebral infarction (P＜0.05). Conclusion The Serum of SAA and haptoglobin levels are correlated with the severity of acute cerebral infarction, and serum SAA level is an independent risk factor for poor outcome of patients with acute cerebral infarction. |
| Key words: Acute cerebral infarction Serum amyloid A Haptoglobin Prognosis |
