| 摘要: |
| 目的研究非小细胞肺癌（NSCLC）患者血清IL-17、血管内皮生长因子（VEGF）水平与临床分期和生存预后的相关性。方法采用酶联免疫吸附实验（ELISA法）检测103例NSCLC患者和50例正常对照者血清IL-17、VEGF水平。分析NSCLC患者血清IL-17和VEGF水平两者之间的关系，分析IL-17、VEGF水平与TNM分期和预后的关系,采用Cox比例风险回归模型进行多因素预后分析。结果NSCLC患者血清IL-17和VEGF水平较正常对照组显著增高（均P＜0.01）。Ⅰ~Ⅱ期与Ⅲ、Ⅳ期患者血清VEGF水平两两比较差异均有统计学意义（均P＜0.05）；血清IL-17水平Ⅰ~Ⅱ期与Ⅲ、Ⅳ期比较，差异均有统计学意义（均P＜0.01），而Ⅲ、Ⅳ期之间比较差异无统计学意义（P＞0.05）。NSCLC患者血清IL-17与VEGF水平呈正相关（r2=0.745，P＜0.01）。血清IL-17、VEGF水平高的患者中位生存时间较短，差异有统计学意义（均P＜0.01）。多因素分析显示，血清IL-17、VEGF水平和TNM分期是独立的预后影响因素（均P＜0.05）。结论NSCLC患者血清IL-17、VEGF水平与NSCLC的TNM分期及生存预后密切相关，两者可作为NSCLC诊断和判断预后的检测指标。 |
| 关键词: 非小细胞肺癌 白介素 -17 血管内皮生长因子 TNM 分期 预后 |
| DOI：10.12056/j.issn.1006-2785.2017.40.6.2017-2377 |
| 分类号: |
| 基金项目:浙江省自然科学基金资助项目（LY17H160063）；浙江省医药卫生科技计划项目（2017KY196） |
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| Correlation of serum IL-17 and VEGF levels with clinical stage and prognosis in patients with non-small cell lung cancer |
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Zhejiang provincial People's Hospital
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| Abstract: |
| Objective To investigate the relationship of serum IL-17 and VEGF with TNM stage and survival in patients with non-small-cell lung cancer (NSCLC). Methods Serum specimens from 103 patients with NSCLC and 50 healthy controls were collected. The concentrations of IL-17 and VEGF were measured using enzyme-linked immunosorbent assay，and the relationship of serum IL-17 and VEGF levels with TNM stage and survival of NSCLC patients was analyzed with COX proportional
hazards regression model. Results Serum IL-17 and VEGF levels were higher in the NSCLC patients than those in the control group (P＜0.01). There were significant differences in the levels of serum IL-17 and VEGF between patients with stage I-II and stage III (P＜0.01), between stage I-II and stage IV (P＜0.01). There was no significant difference in IL-17 levels between stage III and stage IV (P ＞0.05). There was a positive relationship between serum IL-17 and VEGF (r2=0.745, P＜0.01). The median survival time of patients with higher serum IL-17 and VEGF levels was shorter (P＜0.01). Multivariate analysis showed that serum
VEGF and IL-17 levels and TNM stage were independent prognostic factors (P＜0.01). Conclusion The levels of serum IL-17 and VEGF are closely related to the TNM stage and survival of patients with NSCLC, indicating that IL-17 and VEGF might be used as indicators for the diagnosis and prognosis of NSCLC patients. |
| Key words: Non-small cell lung cancer Interleukin -17 VEGF TNM stage Prognosis |
