| 摘要: |
| 目的通过分析重度阻塞性睡眠呼吸暂停综合征（OSAS）患者脑白质扩散张量成像（DTI）的变化，探讨其与认知功能障碍的关系。方法对56例临床确诊的重度OSAS患者（重度OSAS组）与56例年龄、性别和受教育年限相当的志愿者（健康对照组）进行DTI检查，分别于MRI后测量相应脑白质区的各向异性分数（FA）值；检查前采用蒙特利尔认知测量表（MoCA）对两组受检者进行认知功能评价，并分析感兴趣区FA值与MoCA评分、呼吸暂停低通气指数（AHI）之间的相关性。结果重度OSAS组MoCA评分明显低于健康对照组（P＜0.05）。双侧额叶白质、双侧顶叶白质、双侧颞叶白质、双侧半卵圆区、右侧枕叶白质、右侧内囊后支、右侧外囊、胼胝体压部FA值均低于健康对照组（均P＜0.05），其余各区FA值差异均无统计学意义（均P＞0.05）；右侧额叶白质、双侧顶叶白质、右侧枕叶白质FA值与MoCA评分呈正相关（均P＜0.05），右侧额叶白质、右侧外囊、左侧顶叶白质FA值与AHI呈负相关（均P＜0.05）。结论DTI能发现重度OSAS患者脑白质的异常，有助于判断患者认知功能障碍程度和OSAS的严重程度。 |
| 关键词: 阻塞性睡眠呼吸暂停综合征 脑白质 扩散张量成像 认知功能 |
| DOI：10.12056/j.issn.1006-2785.2018.40.9.2017-2668 |
| 分类号: |
| 基金项目:湖州市科技局公益项目（2015GY12） |
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| Correlation of magnetic resonance diffusion tensor imaging findings in white matter with cognitive function impairment in patients with severe obstructive sleep apnea syndrome |
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Huzhou Central Hospital
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| Abstract: |
| Objective To investigate the correlation of magnetic resonance diffusion tensor imaging (DTI) findings in white matter with cognitive function impairment in patients with severe obstructive sleep apnea syndrome (OSAS). Methods Fifty-six patients with severe OSAS (OSAS group) and 56 gender, age and educational level matched healthy subjects (control group) underwent DTI examination, and the anisotropic values (fractional anisotropy FA) were measured on DTI. Before DTI examination the cognitive status was evaluated by with Montreal Cognitive Assessment (MoCA) scale. The relationship among FA value, MoCA score and apnea hypopnea index (AHI) was analyzed in OSAS group. Results The MoCA score of the severe OSAS group was
significantly lower than that of control group (P＜0.05). FA values in white matter of bilateral frontal lobe, parietal lobe, posterior limb
of the internal capsule, right outside capsule, pad of corpus callosum in severe OSAS group were lower than those of the control group (P＜0.05). The FA values in white matter of right frontal lobe, bilateral parietal, right occipital were positively correlated with the MoCA score, and the FA values in white matter of right frontal lobe, right outside capsule and left parietal were negatively correlated
with the AHI. Conclusion DTI can sensitively monitoring the impairment of white matter in severe OSAS patients, which can reflect the severity of cognitive function impairment and severity of OSAS. |
| Key words: Obstructive sleep apnea syndrome White matter Diffusion tensor imaging Cognitive function |
