| 摘要: |
| 目的观察慢性肾脏病（CKD）患者血清脂联素（ADP）水平的变化，并探讨其与性别、年龄、BMI、肾功能、血白蛋白、高敏C反应蛋白（hs-CRP）等因素之间的关系。方法回顾性选取100例CKD患者（CKD组）的临床资料，采用慢性肾脏病流行病学合作公式（CKD-EPI）计算估计肾小球滤过率（eGFR），并以此分为CKD1~5期5个亚组，选取同期健康体检者20例作为正常对照组，分析血清ADP水平与临床指标的相关性。结果CKD组患者女性ADP水平高于男性[(10.46±4.05)滋g/mlvs（8.67±3.06）滋g/ml，P＜0.05]，CKD1~2期组患者(GFR＞60ml·min-1·1.73m-2)ADP水平与正常对照组比较并无统计学差异（P＞0.05），进入CKD3期后，随着肾小球滤过率的进行性下降，患者血清ADP水平急剧升高。CKD患者BMI偏低、eGFR下降、年龄偏小、hs-CRP升高均是ADP水平升高的独立影响因素（均P＜0.05）。结论CKD3~5期患者血清ADP水平明显高于正常人群，从CKD3期开始，CKD患者的血清ADP水平出现明显升高。微炎症状态、BMI、年龄与CKD患者血清ADP水平升高有关。 |
| 关键词: 慢性肾脏病 脂联素 估计肾小球滤过率 微炎症状态 体重指数 |
| DOI：10.12056/j.issn.1006-2785.2018.40.14.2017-2713 |
| 分类号: |
| 基金项目:浙江省中医药科技计划项目（2016ZA060）；浙江省中医药科技计划项目（2016ZA057）；浙江省基础公益研究计划项目（LGF18H050003）；浙江省科技计划项目（2011C33002） |
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| Serum adiponectin level and influencing factors in patients with chronic kidney disease |
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the First Affiliated Hospital of Zhejiang Chinese Medical University
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| Abstract: |
| Objective To investigate serum adiponectin ( ADP ) level in patients with different stage of chronic kidney disease ( CKD ) and its influencing factors. Methods One hundred patients with CKD was enrolled. The estimated glomerular filtration rate (eGFR) was calculated with CKD-EPI formula and patients were divided into CDK1~5 subgroups based on the eGFR value. Twenty healthy subjects were also enrolled as control group. Serum ADP levels were measured and the association of ADP with the clinical features of patients were analyzed. Results Serum ADP was higher in female patients (8.67±3.06滋g/ml) than that in males (10.46±4.05滋g/ml, P＜0.05) . There was no significant difference in serum ADP level between CKD1~2 group and control group ( P ＞0.05). Serum ADP levels were increased with the decrease of eGFR in patients of CKD3~5 group. Multiple linear regression model showed that serum ADP was independently associated with hs-CRP, BMI, eGFR and age of patients（all P＜0.05）. Conclusion Serum ADP level in CKD 3~5 patients are higher than healthy subjects. Micro-inflammatory state, BMI, eGFR and age are related to serum ADP elevation in CKD patients. |
| Key words: Chronic kidney disease Adiponectin eGFR Micro-inflammation state Body mass index |
