| 摘要: |
| 目的系统评价金属基质蛋白酶2（MMP-2）与食管癌临床特征的关系。方法利用PubMed、EMbase、CNKI、维普和万方数据库检索关于MMP-2与食管癌临床特征关系的文献，并进行质量评价。应用Revman5.3软件进行Meta分析。结果共纳入28篇文献。Meta分析结果：MMP-2在食管癌组织中的表达明显高于正常对照组织（OR=10.90，95%CI：7.23~16.44，P＜0.05）；MMP-2与淋巴结转移（OR=4.38，95%CI：3.38~5.48，P＜0.05）、临床TNM分期（OR=2.59，95%CI：1.46~4.58，P＜0.05）、肿瘤浸润深度（OR=5.00，95%CI：3.66~6.83，P＜0.05）、肿瘤直径（OR=1.70，95%CI：1.16~2.49，P＜0.05）、3年生存期（HR=1.46，95%CI：1.16~1.84，P＜0.05）均相关。而MMP-2表达阳性与阴性的食管癌组织分化程度比较，差异无统计学意义（OR=1.51，95%CI：0.77~2.97，P＞0.05）。结论MMP-2与食管癌患者淋巴结转移、临床TNM分期、肿瘤浸润深度、肿瘤直径等有关，与分化程度的关系尚不确定；提示MMP-2在食管癌的发生、发展过程中可能起着重要作用。 |
| 关键词: 食管癌 金属基质蛋白酶 2 Meta 分析 |
| DOI：10.12056/j.issn.1006-2785.2018.40.13.2017-2804 |
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| Clinical significance of MMP-2 expression in esophageal carcinoma: a meta-analysis |
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| Abstract: |
| Objective To investigate the expression and clinical significance of MMP-2 in esophageal carcinoma (EC). Methods PubMed, EMbase, CNKI, VIP and Wanfang databases were searched for relevant literature on the relationship between MMP-2 expression and clinical features of esophageal cancer. The quality of the included studies was evaluated according to the Newcastle-Ottawa Scale (NOS). Statistical analysis was performed using Revman 5.3 software. Results This meta-analysis includes a total of 28 articles. Meta-analysis showed that the expression of MMP-2 in esophageal cancer was higher than that in normal control group (OR=10.90, 95%CI:7.23-16.44, P＜0.05). The positive expression of MMP-2 was associated with the depth of invasion, lymph node metastasis (OR=4.38, 95%CI:3.38-5.48, P＜0.05), clinical stage (OR=2.59, 95%CI:1.46-4.58, P＜0.05), depth of invasion (OR=5.00, 95%CI:3.66-6.83, P＜0.05), tumor size (OR=1.70, 95%CI:1.16~2.49, P＜0.05) and overall survival
(HR=1.46, 95% CI:1.16-1.84, P ＜0.05) in esophageal cancer, but not associated with the differentiation degree of esophageal cancer (OR=1.51, 95%CI: 0.77-2.97, P=0.23). Conclusion The positive expression of MMP-2 is associated with the depth of in- vasion, lymph node metastasis, clinical stage and tumor size in esophageal cancer, indicating that MMP-2 may play an important role in the occurrence and development of esophageal cancer. |
| Key words: Esophageal neoplasms Matrix metalloproteinase-2 Meta-analysis |
