| 摘要: |
| 目的通过分析星形胶质细胞上调基因-1（AEG-1）在非小细胞肺癌（NSCLC）中的表达，探讨其与临床病理特征和血管生成的关系。方法选取NSCLC患者手术切除标本92例，每例标本均留取肿瘤组织和距肿瘤边缘5cm以上的配对远端正常组织，采用免疫组织化学染色方法评估AEG-1表达和微血管密度（MVD），比较肿瘤组织AEG-1高表达和低表达患者临床病理特征及肿瘤组织MVD。结果NSCLC肿瘤组织AEG-1高表达55例（59.78%），远端正常组织AEG-1高表达7例（7.61%），两者比较差异有统计学意义（P＜0.05）。AEG-1高表达患者与AEG-1低表达患者性别、年龄、是否吸烟、肿瘤大小、肿瘤组织类型、肿瘤位置等比较均无统计学差异（均P＞0.05），肿瘤TNM分期、分化程度、是否淋巴结转移等比较均有统计学差异（均P＜0.05）。肿瘤组织MVD高于远端正常组织（P＜0.05）。AEG-1高表达患者肿瘤组织MVD高于低表达患者（P＜0.05）。结论AEG-1在NSCLC发生、发展中起重要作用，并与肿瘤血管生成密切相关，靶向抑制NSCLC患者AEG-1的表达可能是抗肿瘤治疗的有效途径。 |
| 关键词: AEG-1 非小细胞肺癌 血管生成 微血管密度 免疫组织化学 |
| DOI：10.12056/j.issn.1006-2785.2017.39.8.2017-293 |
| 分类号: |
| 基金项目:浙江省自然科学基金青年项目(LQ14H160015)；湖州市公益性技术应用研究一般项目(2013GY17，2014GYB21) |
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| Expression of AEG-1 in non-small cell lung cancer and its relation to clinicopathological features and angiogenesis |
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MA Zhihong, CHEN Yingrong, DONG Shunli, XU Xuting, LIU Jin, SONG Pengtao, LI Hongwei, DAI Licheng
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Huzhou Central Hospital
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| Abstract: |
| Objective To investigate the expression of astrocyte elevated gene-1 (AEG-1) in non-small cell lung cancer (NSCLC) its relation to clinicopathological features and angiogenesis of tumor. Methods Expression of AEG-1, and intratumoral microvessel density (MVD, labeled by CD105) were assessed by immunohistochemistry in 92 NSCLC tissue specimens and corresponding adjacent normal tissue specimens. The relationship of AEG-1 with MVD and clinicopathological features of NSCLC was analyzed. Results The over-expression rate of AEG-1 NSCLC carcinoma tissue was 59.78%(55/92),
which was significantly higher than that in adjacent normal tissue(7.61%, 7/92)(P＜0.05). Upregulated expression of AEG-1 was
significantly associated with clinical stage(P＜0.05), tumor differentiation(P＜0.05), lymph nodes metastasis(P＜0.05), and higher MVD (P ＜0.05) in patients with NSCLC. Conclusion The results suggest that AEG-1 may be involved in malignant transformation and tumor angiogenesis in NSCLC, and targeted inhibition of AEG-1 expression might be a novel strategy for
treatment of NSCLC. |
| Key words: Astrocyte elevated gene-1 Non-small cell lung cancer Angiogenesis Intratumoral microvessel density Immunohistochemistry |
