| 摘要: |
| 目的探讨可溶性fms样酪氨酸激酶1（sFlt-1）对急性胰腺炎（AP）早期诊断及严重程度评估的价值。方法70例AP患者按严重程度分为轻度组43例、中重度组27例；另选同期健康体检者30例为对照组。行血常规、淀粉酶（AMY）、脂肪酶、肝肾功能、空腹血糖（FBG）等检测，采用ELISA法检测不同时点（急诊时及入院第1、2、7天）血清sFlt-1水平。结果中重度组患者血AMY、脂肪酶、TC、FBG、超敏C反应蛋白（hs-CRP）、WBC水平均明显高于轻度组（均P＜0.05）。中重度组血清sFlt-1水平明显高于轻度组、对照组（均P＜0.015），而轻度组又高于对照组（P＜0.05）。入院第1、2天，AP患者血清sFlt-1水平逐渐上升，第7天较急诊时明显下降（P＜0.05）。血清sFlt-1与AMY呈正相关（r=0.360，P＜0.05）。血清sFlt-1与AMY联合检测的AUC明显高于单个指标检测（均P＜0.05），其灵敏度、特异度均优于单个指标检测（均P＜0.05）。结论血清sFlt-1水平在一定程度上能反映AP严重程度，对AP早期诊断及严重程度评估具有一定的参考价值。 |
| 关键词: 急性胰腺炎 可溶性 fms 样酪氨酸激酶 1 早期诊断 严重程度 诊断效能 |
| DOI：10.12056/j.issn.1006-2785.2018.40.18.2017-3143 |
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| Diagnostic value of soluble fms-like tyrosine kinase in acute pancreatitis |
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| Abstract: |
| Objective To investigate the value of soluble fms-like tyrosine kinase 1 ( sFlt-1 ) in diagnosis of acute pancreatitis ( AP). Methods Seventy patients with AP were enrolled and divided into mild group ( MAP group, n=43 ) and moderately/severe group (MSAP group, n=27), 30 healthy subjects were simultaneously enrolled as the control group (n=30). Blood routine, amylase (AMY), lipase, liver and kidney function, fasting blood glucose (FBG) and other indicators were measured. Serum sFlt-1 was detected by enzyme-linked immunosorbent assay( ELISA ) at emergency admission and 1d, 2d, 7d after admission. Results The blood AMY, lipase, TC, FBG, high-sensitivity C-reactive protein (hs-CRP) and WBC levels were significantly higher in the MSAP group than those in the MAP group (P＜0.05). The level of serum sFlt-1 in MSAP group was significantly higher than that in MAP group and control group (P＜0.05) and serum sFlt-1 levels in MAP group were significantly higher than those in control group (P＜0.05). Serum sFlt-1 levels in AP patients gradually increased on the 1st and 2nd day after admission, but decreased significantly on the 7th day, and significantly lower than that at admission(P＜0.05). There was a
positive correlation between serum sFlt-1 and blood AMY levels (r=0.360, P＜0.05). ROC curve analysis showed that the area under the curve(AUC) of the combined detection of AMY and sFlt-1 was significantly higher than sFlt-1, AMY alone (P＜0.05). The sensitivity and specificity of the combined detection were better than single index (P＜0.05). Conclusion Serum sFlt-1 levels can reflect the severity of the disease in some extent. It has a certain clinical reference value in diagnosis and severity assess- ment of acute pancreatitis. |
| Key words: Acute pancreatitis Soluble fms-like tyrosine kinase 1 Early diagnosis Severity Diagnostic effi- ciency |
