| 摘要: |
| 目的探讨乳腺癌腋窝淋巴结转移的危险因素，为术前初步预测淋巴结转移情况提供参考依据。方法回顾性分析738例乳腺癌患者的临床病理资料，进行单因素及多因素分析，筛选危险因素。结果单因素分析结果显示，肿瘤大小、肿瘤位置、脉管浸润、病理类型、组织学分级、ER、PR、Ki-67与乳腺癌腋窝淋巴结转移相关（P＜0.05或0.01），患者年龄、家族史、Her-2状态与乳腺癌腋窝淋巴结转移无关（均P＞0.05）。多因素分析结果显示，进入模型的危险因素有7个，分别是肿瘤大小、肿瘤位置、脉管浸润、病理类型、组织学分级、ER、Ki-67（OR=1.902、0.563、2.821、0.183、1.528、2.236、1.498，P＜0.05或0.01）。结论肿瘤大小、肿瘤位置、脉管浸润、病理类型、组织学分级为乳腺癌腋窝淋巴结转移的独立危险因素。 |
| 关键词: 乳腺癌 腋窝淋巴结转移 危险因素 |
| DOI：10.12056/j.issn.1006-2785.2018.40.3.2017-414 |
| 分类号: |
| 基金项目:嘉兴市科技局一般科技计划（2015AY23034） |
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| Risk factors of axillary lymph node metastasis in breast cancer |
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Jiaxing Maternal and Child Health Hosptial
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| Abstract: |
| Objective To analyze the risk factors of axillary lymph node metastasis in breast cancer. Methods The clinicopathologic data of 738 patients with breast cancer admitted in our hospital were retrospectively reviewed. The risk factors of axillary lymph node metastasis were analyzed by Logistic regression. Results The tumor size, tumor location, vascular invasion, pathological type, histological grade, ER and PR status, Ki-67 were significant associated with axillary lymph node
metastasis (P＜0.05); while age, family history, Her-2 status were not associated with axillary lymph node metastasis. Logistic
regression revealed that tumor size, tumor location, vascular invasion, pathological type, histological grade, ER status and Ki-67 were independent risk factors of axillary lymph node metastasis (OR =1.902, 0.563, 2.821, 0.183, 1.528, 2.236 and 1.498, respectively). Conclusion Tumor size, tumor location, vascular invasion, pathological type, histological grade are independent risk factors of axillary lymph node metastasis in breast cancer. |
| Key words: Breast cancer Axillary lymph node metastasis Risk factors |
