| 摘要: |
| 目的研究阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者体内血清缺血修饰蛋白（IMA）水平变化，探讨IMA对OSAHS的诊断价值。方法选择门诊拟诊OSAHS的患者108例，根据多导睡眠监测结果，分为OSAHS组63例，控制组45例。两组患者于多导睡眠监测当天19:00及次日7:00分别抽取静脉血检测IMA，比较各组不同时点间及两组相同时点间IMA水平。进一步分析IMA水平与AHI的相关性，绘制ROC曲线评价IMA对OSAHS的诊断价值。结果OSAHS组7:00与19:00的IMA水平均明显高于控制组，差异均有统计学意义（均P＜0.05）。OSAHS组7:00的IMA水平显著高于19:00的IMA水平，差异有统计学意义（P＜0.01）。控制组7:00与19:00的IMA水平比较差异无统计学意义（P＞0.05）。7:00及19:00的IMA水平与AHI均呈正相关（r=0.681和0.583，均P＜0.01）。根据7:00不同IMA临界值所对应诊断OSAHS的灵敏度和特异度描绘的ROC曲线，AUC为0.883，IMA最佳临界值为70.26U/L，以IMA≥70.26U/L为标准诊断OSAHS的灵敏度为0.84，特异度为0.78。结论IMA在OSAHS患者体内明显升高，是一个有助于诊断OSAHS的良好血清学指标。 |
| 关键词: 阻塞性睡眠呼吸暂停低通气综合征 缺血修饰蛋白 诊断 |
| DOI：10.12056/j.issn.1006-2785.2018.40.7.2017-485 |
| 分类号: |
| 基金项目:杭州市富阳区科技局项目（2013SF023） |
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| Diagnostic value of ischemia modified albumin in patients with obstructive sleep apnea hyponea syndrome |
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Hangzhou Fuyang District First People's Hospital
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| Abstract: |
| Objective To determine the diagnostic value of ischemia modified albumin (IMA) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods A total of 108 patients with clinically suspicious OSAHS were enrolled. All cases underwent whole-night polysomnographic (PSG) monitoring. Serum IMA levels were detected at 19:00 of d1 and 7:00 of d2, respectively. Results The IMA levels of the OSAHS group both at 7:00 and 19:00 were significantly higher than those in the control group (both P＜0.01). The IMA levels of the OSAHS group at 7:00 was higher than that of IMA at 19:00 (P＜0.05). There was no significant difference in IMA levels between the control group at 7:00 and 19:00 (P ＞0.05). IMA levels at 7:00 and 19:00 were both positively correlated with apnea hyponea index (AHI) (r= 0.681 and 0.583, both P＜0.01). when the cut-off threshold
derived from the ROC curve was determined to be 70.26U/L at 7:00, the sensitivity and specificity in diagnosis of OSAHS were
0.84 and 0.78, respectively. Conclusion IMA may be a valuable serological indicator for diagnosis of OSAHS. |
| Key words: Obstructive sleep apnea hypopnea syndrome Ischemia modified albumin Diagnosis |
