| 摘要: |
| 目的探讨视听整合持续操作测验（IVA-CPT）和事件相关电位P300在注意缺陷多动障碍（ADHD）患者中的相关性及其临床诊断中的应用价值。方法将符合DSM-V中ADHD诊断标准的30例患儿和30例健康儿童进行IVA-CPT检测和注意缺陷多动障碍筛查量表中文版（SNAP-IV）评估。同时运用视觉oddball范式，记录P300脑电信息参数。结果在IVA-CPT测试中，ADHD患者的综合注意力商数、综合控制力商数、听觉/视觉控制力商数和听觉/视觉注意力商数均显著降低（均P＜0.01）。ADHD患者及三个亚型与对照组相比，P300的潜伏期延长、波幅降低（P＜0.05或0.01），尤在Cz更显著；但是波幅下面积各组间无统计学差异。另外，ADHD患者IVA-CPT的视觉注意力商数和视觉控制力商数与P300波幅呈正相关（P＜0.05或0.01）；而与P300潜伏期呈负相关（P＜0.01）。结论ADHD患者的P300有显著改变，主要表现为P300潜伏期延长和波幅降低，可能与注意反应延缓和抑制控制损害有关。提示ADHD患者存在神经认知功能异常。 |
| 关键词: 注意缺陷多动障碍 事件相关电位 P300 注意缺陷多动障碍筛查量表 视听整合持续操作测验 注意功能 |
| DOI：10.12056/j.issn.1006-2785.2017.39.23.2017-550 |
| 分类号: |
| 基金项目:浙江省自然科学基金（LY13H090012） |
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| Correlation of visual event-related potential P300 with audio-visual continuous performance test in children with attention deficit hyperactivity disorder |
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the Second Affiliated Hospital of Zhejiang Chinese Medical University
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| Abstract: |
| Objective To investigate the correlation of visual event-related potential P300 with integrated visual auditory continuous performance test (IVA-CPT) in children with attention deficit hyperactivity disorder (ADHD). Methods Thirty children with ADHD and 30 normal children (control group) were enrolled in the study. The visual oddball paradigm was applied, P300 was
measured; and the IVA-CPT and SNAP-IV was assessed in all patients and controls. Results The full and secondary scales for attention and response accuracy on the IVA-CPT in children with ADHD were significantly lower compared to normal controls (P＜ 0.01). Children with ADHD showed a significantly longer latency and lower amplitude of P300 compared to normal children, especially for Cz (P＜0.05 or P＜0.01). There were no differences in the area below the wave amplitude between children with
ADHD and controls. The visual attention quotient and visual response control quotient were positively correlated with P300(P＜0.05 and P ＜0.01), and negatively correlated with the latency of P300 (P ＜0.01). Conclusion The endogenous ERPs (P300) is significantly affected in children with ADHD; the increased latency of P300 suggests a slower processing speed, and decreased
P300 amplitude suggests the inhibitory control in children with ADHD. These results indicate a neurocognitive abnormality in ADHD. |
| Key words: Attention deficit hyperactivity disorder Event-related potentials P300 SNAP-IV IVA-CPT Attention |
