| 摘要: |
| 目的通过Meta分析探讨创伤性颅脑损伤（TBI）与阿尔茨海默病（AD）发生的关系。方法检索数据库，检索截止至2016年9月已公开发表的所有分析TBI与AD发生的相关文献，筛选文献、提取资料、评价文献质量，使用统计软件进行Meta分析。结果本研究纳入23项非随机对照研究[9项病例对照研究，11项队列研究，3项横截面研究，总样本量2184210例（病例组179737例，对照组2004473例）]。对以AD群体为研究基础的18项研究进行合并后，结果显示TBI为AD可疑危险因素（OR=1.362，95%CI：0.996~1.863，P＞0.05）。而对以TBI群体为研究基础的5项研究进行合并后，结果显示TBI为AD的危险因素（OR=2.536，95%CI：1.763~3.648，P＜0.05）。结论TBI有增加AD发生的风险，但仍需更多中心、更大样本的随机对照研究进一步论证。 |
| 关键词: 创伤性颅脑损伤 阿尔茨海默病 危险因素 Meta 分析 |
| DOI：10.12056/j.issn.1006-2785.2017.39.24.2017-712 |
| 分类号: |
| 基金项目:浙江省中医药科技计划项目（2015ZA123） |
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| Relationship between traumatic brain injury and Alzheimer's disease: a Meta-analysis |
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Hangzhou First People's Hospital
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| Abstract: |
| Objective To evaluate the relationship between traumatic brain injury (TBI) and Alzheimer's disease (AD). Methods The studies related the relationship TBI and AD were retrieved from database till September 2016, the quality of the literature was evaluated and analyzed with Stata 11.0. Results Twenty three non-randomized controlled trials (9 case-control studies, 11 cohort studies and 3 cross-sectional studies) were included in the study. The total sample size was 2 184 210 cases
(179 737 cases, 2 004 473 controls). After 18 AD population-based studies were pooled, the results showed that TBI was a suspected risk factor for AD (OR=1.362, 95%CI:0.996-1.863, P ＞0.05). After 5 TBI population based studies were pooled, the results showed that TBI was a risk factor for AD(OR=2.536, 95%CI:1.763-3.648, P＜0.05). Conclusion TBI is associated with the occurrence of AD, and further large scale randomized controlled trials are needed for confirm the results. |
| Key words: Traumatic brain injury Alzheimer's disease Risk factors Meta-analysis |
