| 摘要: |
| 目的研究TNF-α-1031T/C基因多态性与精神分裂症患者发病年龄、认知功能的关系。方法选择486例住院精神分裂症患者为观察组，319例年龄、性别、受教育年限与观察组相匹配健康志愿者为对照组，采用重复性成套神经心理状态测验（RBANS）评估其认知功能，采用聚合酶链式反应-限制性酶切片段长度多态性（PCR-RFLP）法进行基因分型，分析TNF-α-1031T/C基因多态性与精神分裂症患者发病年龄、认知功能的关系。结果观察组与对照组TNF-α-1031T/C基因型及等位基因分布频率比较，差异均无统计学意义（均P＞0.05）。TT基因型与TC+CC基因型的精神分裂症患者年龄，性别，病程，阳性与阴性症状量表（PANSS）总分及各因子得分，RBANS的注意、言语功能及延迟记忆等分量表得分比较，差异均无统计学意义（均P＞0.05）。TT基因型患者发病年龄小于TC+CC基因型患者，RBANS总分及即刻记忆、视觉广度等分量表得分均低于TC+CC基因型，差异均有统计学意义（均P＜0.05）。精神分裂症患者发病年龄与RBANS总分及注意、即刻记忆、延迟记忆等分量表得分均呈正相关（r=0.179、0.102、0.154和0.134，均P＜0.05），与视觉广度、言语功能分量表得分均未见相关（r=0.149和0.138，均P＞0.05）。中介效应模型分析发现，精神分裂症患者发病年龄在认知功能损害中发挥了部分中介的作用（R2=0.13，P＜0.01）。结论TNF-α-1031T/C基因多态性可能是引起精神分裂症患者认知功能损害的原因之一，或通过影响发病年龄而导致认知功能损害。 |
| 关键词: 精神分裂症 基因多态性 认知功能 发病年龄 |
| DOI：10.12056/j.issn.1006-2785.2017.40.4.2017-938 |
| 分类号: |
| 基金项目:温州市公益性科技计划项目（Y20160103） |
|
| TNF-琢-1031 T/C polymorphisms is associated with cognitive dysfunction in chronic schizophrenia |
|
|
|
Affiliated Kangning Hospital of Wenzhou Medical University
|
| Abstract: |
| Objective To investigate the association of TNF-α-1031 T/C polymorphisms with the age of onset and cognitive functions of patients with schizophrenis. Methods Total 486 patients with schizophrenia and 310 age-, sex- and education level-matched healthy subjects (control group) were enrolled in the study. Cognitive functions were measured by RBANS and symptoms were assessed by PANSS. The TNF-α-1031 T/C polymorphisms were detected by PCR-RFLP. Results There were no significant differences in allelic frequency and genotype frequency in TNF-α-1031 T/C between patients and normal controls. However, the TNF-α-1031 T/C polymorphisms were significantly associated with the age of onset (P＜0.05), immediate memory, visuospatial, total score of RBANS (P ＜0.05) in schizophranic patients. The age of onset was related to
attention, immediate memory, delayed memory and total score of RBANS (r=0.179, 0.102, 0.154, 0.134, all P ＜0.05). It is significant for the mediation analysis for the relationship across TNF-α-1031 T/C polymorphism, age of onset and cognitive functions. Conclusion The results indicate that TNF-α-1031 T/C polymorphism may be one of the causes for cognitive impairments, which may be associated with the age of onset in patients with schizophrenia. |
| Key words: Schizophrenia Gene polymorphism Neurocognitive function Episode age |
