| 摘要: |
| 目的探讨孕早期母体甲状腺激素水平与孕中期增重的相关性。方法选择行孕期保健的孕妇2533例，检测其孕早期、孕中期和孕晚期甲状腺激素水平,包括游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）和促甲状腺激素（TSH）。采用Pearson相关及混合线性效应回归模型分析孕早期母体甲状腺激素水平与孕中期增重的关系。结果随着孕期的增长，孕妇血清TSH逐渐升高，FT3和FT4逐渐降低，差异均有统计学意义（均P＜0.05）。经Pearson相关分析，无论整体还是BMI分层下，孕早期TSH、FT3、FT4与孕中期增重均无相关性（均P＞0.05），调整孕妇年龄、BMI、分娩孕周、孕周差及TSH、FT3、FT4影响后，经线性回归分析，孕早期TSH、FT3、FT4水平与孕中期增重亦均无相关性（均P＞0.05）。结论孕早期母体甲状腺激素水平与孕中期增重没有相关性。 |
| 关键词: 妊娠 甲状腺激素 体质量 相关性 |
| DOI：10.12056/j.issn.1006-2785.2017.39.4.2016-1240 |
| 分类号: |
| 基金项目:浙江省医药卫生科研基金项目（2015KYA229）；浙江省医药卫生科研基金项目（2017KY683）；浙江省医药卫生科研基金项目（2017KY684） |
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| Correlation between maternal thyroid hormone levels in early pregnancy and weight gain in pregnant metaphase |
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WANG Junfen, WU Jinhua, JIANG Wen, XU Haigeng, LV Yun, WEI Yufeng, LI Xiawei, MO Minjia, WANG Shuojia, YU Yunxian
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Zhoushan Matenal and Child Health Hosptial
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| Abstract: |
| Objective To investigate the correlation between maternal thyroid hormone levels in early pregnancy and
weight gain in pregnant metaphase. Methods Total 2 533 pregnant women who received prenatal care province were recruited in the study. Serum levels of thyroid hormones TSH, FT3, FT4 were measured and the relationship between thyroid hormone level during 1st trimesters and the weight gain in the 2st trimester of pregnancy was analyzed by Pearson correlation and linear regression model. Results According to the inclusion, exclusion and rejection criteria, 1 971 of 2 533 cases were included in the
analysis. The serum TSH levels were gradually increased and FT3 and FT4 levels were gradually decreased in early, middle and late pregnant women (all P＜0.05). Pearson analysis showed that both in overall analysis or after BMI stratification there was no correlation between serum TSH, FT3, FT4 levels in early pregnancy and weight gain in pregnant metaphase (all P ＞0.05). After adjustment of maternal age, maternal BMI, gestational age, D-value of gestational age, TSH, FT3, FT4 levels, the linear regression showed the same results (all P ＞0.05). Conclusion It has no significant correlation betweenmaternal thyroidhormone levels in early pregnancyandweightgaininpregnantmetaphase. |
| Key words: Pregnancy Thyroid hormone Body mass Correlation |
