| 摘要: |
| 目的：研究比较两种高孕酮方案即内源性高孕黄体期和外源性高孕卵泡期促排卵方案在卵巢低反应患者中的应用。方法：回顾性分析2016年1月至2016年12月205个体外受精（IVF）/卵胞浆内单精子显微注射技术（ICSI）-胚胎移植周期。根据用药方式不同分为2组，高孕激素环境下超促排卵方案（PPOS）138个周期黄体期促排卵方案（LPOS）67个周期。比较两者促排卵结果、实验室相关指标及临床妊娠结局。结果：两组之间年龄、获卵数、D3优质胚胎数均无显著差异（P>0.05）。在PPOS方案比LPOS方案，触发日LH水平要更高（P＜0.05），而在触发日P水平、Gn总量、卵子成熟率，则更低（P<0.05）。两组间的优质胚胎率、后期冻融胚胎移植的临床妊娠率均没有差异（P>0.05）。并且两组中均没有发生早发LH峰和OHSS。结论：对两种不同来源的高孕激素状态下促排卵，LPOS和PPOS，均能使POR患者获得理想的优胚率以及冻融胚胎移植临床妊娠率。两种方案均适用于POR患者，这能使促排卵受月经周期影响减小，使启动时间更加灵活，同时也可减少患者来回医院的路途奔波。 |
| 关键词: 黄体期促排卵，卵泡期高孕激素，卵巢低反应，冻融胚胎移植 |
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| Compare the two ways of using progesterone to ovulation induction in poor ovarian responders |
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YangTanchu1, ChenHaoying1, XiHaitao2, ZhaoJunzhao2
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1.Wenzhou Medical University;2.The 2nd Affiliated Hospital and Yuying Children’s Hospital of WenZhou Medical University,
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| Abstract: |
| Abstract:objective:To compare the two ways of using progesterone (endogenous as with Luteal-phase ovarian stimulation (LPOS),or exogenous as with the use of progesterone in the follicular phase (progestin primed ovarian stimulation,PPOS)) used to ovulation induction in poor ovarian responders. Methods:From January 2016 to December 2016,205 IVF/ICSI cycles were analysed retrospectively.138 cycles adopted PPOS protocol and 67 cycles adopted LPOS protocol. Comparison of two methods to the results of induce ovulation, laboratory - related indicators and clinical outcomes.Results：The age and the number of retrieved oocytes and D3 high quality embryos were similar between two groups(P>0.05).The LH level of trigger day is higher in PPOS protocol(P<0.05),the dose of Gn and progesterone level and mature oocytes rate are much lower during progestin primed ovarian stimulation.No significant difference was found in good-quality embryos rate (55.75%vs58.39%) and clinical pregnancy rate (21.35%vs18.37%) (P>0.05) frozen-thawed embryo transfer (FET) cycle in the PPOS and LPOS, respectively. No premature LH surge and OHSS occurred in either group. Conclusion: LPOS and PPOS can both achieve the ideal good-quality embryos rate and clinical pregnancy rate of first frozen-thawed embryo transfer. Both are suitable for POR,which can reduce the impact of menstrual cycle to make the start-up time more flexible, but also can reduce the patient's back and forth to the hospital. |
| Key words: Luteal phase ovarian stimulation / progestin primed ovarian stimulation/ poor ovarian response/ frozen-thawed embryo transfer |