| 摘要: |
| 目的分析妊娠期妇女血清25-羟基维生素D（25-OH-VD）水平对围生结局的影响，阐明妊娠期适当补充维生素D的重要性。方法选取常规产检的妊娠期妇女1502例，于妊娠20周左右测定血清25-OH-VD水平。将孕妇分为血清25-OH-VD水平＜50nmol/L425例（维生素D缺乏组）和血清25-OH-VD水平≥50nmol/L1077例（维生素D正常组）两组。两组孕妇进行常规孕期检查，包括口服葡萄糖耐量试验，监测血压，分娩时记录分娩孕周、是否胎膜早破、新生儿出生体重、产后出血情况、产褥感染情况。结果维生素D缺乏组孕妇妊娠期糖尿病、子痫前期、早产和足月小样儿发生率均高于维生素D正常组孕妇，差异均有统计学意义（均P＜0.05）。两组胎膜早破、产后出血和产褥感染发生率比较差异均无统计学意义（均P＞0.05）。结论妊娠期妇女维生素D缺乏将增加围生期并发症的发生，对维生素D缺乏孕妇及时补充维生素D制剂，提高孕妇血清25-OH-VD水平，对改善围生结局具有重要意义。 |
| 关键词: 25- 羟基维生素 D 围生结局 影响 |
| DOI：10.12056/j.issn.1006-2785.2018.40.10.2018-40 |
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| Effect of serum 25-OH-VD levels during pregnancy on perinatal outcome |
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the Second Affiliated Hospital of Wenzhou Medical University
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| Abstract: |
| Objective To investigate the effect of serum 25-OH-VD levels on perinatal outcome in pregnant women. Methods Serum 25-OH-VD levels were measured in 1 502 pregnant women underwent routine prenatal examinations in our hospital. There were 425 cases with serum 25-OH-VD level ＜50nmol/L (vitamin D deficiency group) and 1 077 cases with serum 25-OH-VD level ≥ 50nmol/L (vitamin D normal group). The oral glucose tolerance test and monitoring blood pressure were measured; the gestational age, premature rupture of membranes, neonatal birth weight, postpartum hemorrhage and puerperal infection were documented and compared between two groups. Results The incidence of gestational diabetes, preeclampsia,
preterm labor and small-for-date infant in vitamin D deficiency group were significantly higher than that in vitamin D normal group (all P＜0.05). There were no significant differences in the incidence of premature rupture of membranes, postpartum hem- orrhage and puerperal infection between the two groups (all P ＞0.05). Conclusion Vitamin D deficiency in pregnant women will increase risk of perinatal complications. Appropriate supplementation of vitamin D during pregnancy to improve serum 25-OH-VD level is of great significance in improving perinatal outcomes. |
| Key words: 25-hydroxy-vitamin D Perinatal outcomes Influence |
