| 摘要: |
| 目的探讨扫描式葡萄糖监测系统（FGM）动态监测的组织液葡萄糖与毛细血管快速血糖（CBG）的相关性，并考察其独立指导糖尿病治疗的可行性。方法对36例住院糖尿病患者扫描FGM探头葡萄糖（SG）与CBG[使用FGM系统内置血糖仪（CBGF）、强生OneTouch稳豪倍优型血糖仪（CBGL）进行测定]的相关性进行分析，同时使用奥森多全自动干式生化分析仪vitros350测定外周静脉血（浆）葡萄糖（PBG）。在植入FGM探头的第2~4天进行1次100g馒头餐试验，以观察3种血糖检测方法餐后血糖的变化。结果SGvsCBGF，绝对差值相对数的均数（MARD）值为10.4%（r2=0.97）；SGvsCBGL，MARD值为11.3%（r2=0.97）。SGvsCBGF馒头餐，MARD值为10.9%（r2=0.96）；SGvsCBGL馒头餐，MARD值为11.2%（r2=0.96）。经Clarke误差表格分析，A区比例分别为88.7%（SGvsCBGF）、85.2%（SGvsCBGL）。在馒头餐试验中，SG低于CBG、PBG，其上升速度也更缓慢。结论FGM的SG与CBG的相关性良好，探头监测与其内置血糖仪的长期或按需应用作为不同类型糖尿病患者的监测手段实际可行；但SG可能低估餐后血糖波动水平。 |
| 关键词: 扫描式葡萄糖监测系统 持续葡萄糖监测 相关性 可行性 |
| DOI：10.12056/j.issn.1006-2785.2017.40.11.2018-406 |
| 分类号: |
| 基金项目: |
|
| Consistence of interstitial glucose measured by the flash glucose monitoring system with capillary blood glucose |
|
|
|
Ningbo Medical Treatment Center Lihuili Hospital
|
| Abstract: |
| Objective To assess the consistence between interstitial fluid (ISF) glucose retrieved by the flash glucose monitoring system (FGM) and capillary blood glucose by point-of-care testing, and to evaluate the feasibility of FGM as a non-adjunctive glucose monitoring in diabetes management. Methods Thirty six diabetic patients admitted from March to December 2017 were enrolled in the study, including 8 cases of type 1 diabetes mellitus, 27 cases of type 2 diabetes mellitus and 1 case of post-pancreatitis diabetes. Scanned sensor glucose values were measured by FGM, capillary blood glucose(CBG) were measured simultaneously by two BG meters [the BG meter integrated with FGM (CBGF), and the OneTouch ultravue meter, LifeScan (CBGL)], and the values were paired up and compared. Plasma glucose was measured with Ortho vitros 350 Chemistry System. A standard carbohydrate tolerance test was arranged during day 2 to 4 after insertion of glucose sensor in order to observe the performance of different glucose monitoring methods in postprandial phase. Results The mean absolute relative difference (MARD) were 10.4% (r2=0.97), 11.3% (r2=0.97), with a percentage of 88.7%, 85.2% measurements distributing in zone A in SG vs CBGF, SG vs CBGL, respectively. The MARD was 10.9% (r2=0.96) compared to PBG. SG values during the postloaded phase showed a slower rise and generally lower values than CBG and PBG measurements. Conclusion Sensor glucose mea- surements were significantly consistent with capillary blood glucose measurements and plasma blood glucose. It is a valuable al- ternative for self-monitoring of glucose. But it may underestimate postprandial glucose excursion. |
| Key words: Flash glucose monitoring Continuous glucose monitoring Correlation Feasibility |
