| 摘要: |
| 目的 研究维生素K4与甲硝唑联合牙周基础治疗术治疗慢性乙型肝炎肝硬化患者牙龈出血的近期疗效。 方法 纳入慢性乙型肝炎肝硬化牙龈出血患者92例，随机分为三组，A组采用单用维生素K4，B组采用甲硝唑联合牙周基础治疗术，以及C组采用维生素K4与甲硝唑联合牙周基础治疗术治疗，观察各组疗效。3组均在治疗前及治疗完成后1月进行牙周临床检查，观察指标包括探诊深度（probing depth，PD）和龈沟出血指数（sulcus bleeding index，SBI）。
结果 C组的近期有效率高于B组（P<0.05），B组高于A组（P<0.01）。治疗前各组间牙周指标比较差异无统计学意义（P>0.05），组内比较治疗完成后1月比治疗前差异有统计学意义（P<0.01），治疗完成后1月组间比较C组优于B组（P<0.05），B组优于A组（P<0.01），差异有统计学意义。结论 牙周局部病变是慢性乙型肝炎肝硬化牙龈出血的一个主要原因，维生素K4能有效改善牙龈出血症状，维生素K4与甲硝唑联合牙周基础治疗术治疗慢性乙型肝炎肝硬化患者牙龈出血近期疗效好，值得临床推广。 |
| 关键词: 肝硬化 牙龈出血 牙周基础治疗 维生素K4 甲硝唑 |
| DOI： |
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| 基金项目:浙江省医药卫生科技项目(2014KYB018) |
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| Short term efficacy observation of vitamin K4 and metronidazole combined with periodontal initial therapy in the treatment of chronic hepatitis B cirrhosis patients with gingival bleeding |
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陈云芳1, pan hong ying2, huang hai jun2
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1.Zhejiang Provincial People''s Hospital/Affiliated Hospital of Hangzhou Medical College;2.Zhejiang Provincial People's Hospital/Affiliated Hospital of Hangzhou Medical College
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| Abstract: |
| Objective To study short term effects of vitamin K4 and metronidazole combined with periodontal initial therapy in the treatment of chronic hepatitis B cirrhosis patients with gingival bleeding. Methods A totoal of 92 patients with gingival bleeding were randomly divided into three groups. Patients in group A were treated with vitamin K4, group B were treated with metronidazole combined with periodontal initial therapy, and group C were treated with vitamin K4 and metronidazole combined with periodontal initial therapy. The curative effect was observed. Clinical periodontal examinations including probing depth (PD) and sulcus bleeding index(SBI) were observed at baseline and one month post-treatment by the same examiner. Results The short term effectiveness of group C was higher than group B（P<0.05）, group B was much higher than group A（P<0.01）. Each periodontal index was no significant difference between the groups at baseline（P>0.05）. However, the difference of each periodontal index among three groups was statistically significant before and after one month treatment.Comparison of each periodontal index one month post-treatment, group C was better than group B（P<0.05），and group B was better than that of group A（P<0.01）. Conclusion The main cause of gingival bleeding in patients with chronic hepatitis B cirrhosis is local periodontal disease, vitamin K4 could effectively improve the gingival bleeding symptoms, vitamin K4 and metronidazole combined with periodontal initial therapy is relatively efficient method in the treatment of chronic hepatitis B cirrhotic gingival bleeding. It is worthy of clinical application. |
| Key words: liver cirrhosis gingival bleeding periodontal initial therapy vitamin K4 metronidazole |