| 摘要: |
| 探讨单羧酸转运蛋白1（mono-Carboxylate transporters 1，MCT1）和葡萄糖转运蛋白1 (Glucose transporter 1 ，Glut-1)在人直肠癌组织中的表达在癌症发生发展中的临床意义。方法：应用免疫组织化学的方法检测75例直肠癌及32例对照组直肠组织标本中Glut-1蛋白以及MCT1蛋白表达水平。结果：在对照组直肠组织中检测到1例Glut-1蛋白的表达，占比3.13%,而直肠癌组检测到59例Glut-1蛋白的阳性表达，占比78.67%，差异有统计学意义（P<0.05）；Glut-1蛋白的阳性表达率与直肠癌TNM分期以及淋巴结转移有关(P<0.05)；在对照组直肠组织中MCT1蛋白阳性表达率较低为6.25%,而直肠癌组织中MCT1蛋白表达率较高为62.67%，差异有统计学意义（P<0.05）；MCT1蛋白表达量与直肠癌TNM分期以及淋巴结转移有关(P<0.05)；在72例直肠癌组织中，Glut-1蛋白与MCT1蛋白表达的阳性率呈显著正相关（r=0.338，P<0.05）；进一步分析发现，二者的表达水平在直肠癌组织中，呈线性相关（r=0.639，P<0.05）。结论：MCT1与GLUT-1蛋白的表达水平在肠癌患者组织中呈现显著正相关，暗示着两者在疾病发生发展过程中可能存在一定的协同作用，共同发挥生理功能，为进一步对肠癌患者进行临床治疗提供了实验支持和理论依据。 |
| 关键词: 单羧酸转运蛋白1 葡萄糖转运蛋白1 直肠癌 |
| DOI： |
| 分类号: |
| 基金项目:能量代谢共生作用关键分子（GLUT1和MCT1/4）与结肠癌FOLFOX化疗方案临床预后相关性研究 |
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赵盼, zhou hong, wu jian
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Hangzhou First People''s Hospital
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| Abstract: |
| Objective: To investigatemono-Carboxylate transporters 1 and Glucose transporter 1 ，Glut-1 in the clinical significance of the expression in human colorectal cancer in the development and progression of cancer.
Methods: Immunohistochemical method was used to detect the expression of Glut-1 protein and MCT1 protein in rectal tissues of 75 rectal cancer patients and 32 controls.
Results: In the rectum of the control group, the expression of Glut-1 protein was detected in one case, accounting for 3.13%. In the rectal cancer group, positive expression of 59 Glut-1 protein was detected, accounting for 78.67%, and the difference was statistically significant (P <0.05); The positive expression rate of Glut-1 protein was related to rectal cancer TNM staging and lymph node metastasis (P<0.05); in the control group rectal tissue MCT1 protein positive expression rate was lower 6.25%, and rectal cancer tissue MCT1 The protein expression rate was 62.67%, and the difference was statistically significant (P<0.05). The expression of MCT1 protein was correlated with TNM staging of colorectal cancer and lymph node metastasis (P<0.05); in 72 cases of rectal cancer tissue, Glut-1 There was a significant positive correlation between the positive rate of protein and MCT1 protein expression (r=0.338, P<0.05). Further analysis found that the expression levels of both proteins were linearly correlated in rectal cancer tissue (r=0.639, P<0.05).
Conclusion: The expression level of MCT1 and GLUT-1 protein shows significant positive correlation in the tissues of patients with colorectal cancer, suggesting that both of them may have a certain synergistic effect in the course of the disease and develop the physiological function, which provides experimental support and theoretical basis for the further clinical treatment of colorectal cancer patients.
Keywords: mono-Carboxylate transporters 1; Glucose transporter 1; Rectal cancer |
| Key words: mono-Carboxylate transporters 1 Glucose transporter 1 Rectal cancer |