| 摘要: |
| 目的：揭示血清细胞粘合素-C浓度与重型颅脑损伤伤情及30天死亡的关系。方法：检测130例重型颅脑损伤患者及130例健康对照组血清细胞粘合素-C浓度。采用入院时格拉斯哥昏迷评分评价伤情严重度,预后评价指标包括30天的死亡率和生存时间。统计学方法包括双变量分析、多因素分析和受试者工作特征曲线分析。结果：重型颅脑损伤患者血清细胞粘合素-C浓度较对照组显著升高。重型颅脑损伤患者血清细胞粘合素-C浓度与入院时格拉斯哥昏迷评分和30天死亡率和生存时间呈独立显著性相关,且可显著预测30天死亡。结论：增高的血清细胞粘合素-C浓度可反映颅脑损伤伤情严重度及死亡。 |
| 关键词: 颅脑损伤 细胞粘合素-C 严重度 死亡 |
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| 基金项目:杭州市科技计划项目(重型颅脑损伤患者住院期间并发主要不良事件的早期预警指标研究,项目编号：20180533B43) |
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| Correlative analysis between serum tenascin-C concentrations and 30-day death of patients with severe traumatic brain injuryKe Xin, Yang Ming Chen Fanghui, Wang Yi, et al. Department of Critical Medicine, the Taizhou First People’s Hospital, Taizhou 318020, Zhejiang Province, China. |
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柯欣1, Yangming1, Cheng fanghui2, Wangyi2, Zheng yongke2, Huwei2, Dongxiaoqiao2, DUquan2, Yu wenhua2
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1.The Taizhou First People’s Hospital;2.The Hangzhou First People’s Hospital
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| Abstract: |
| Objective: To ascertain relationship between serum tenascin-C concentrations, trauma severity and 30-day mortality in patients with severe traumatic brain injury (TBI). Methods: Serum tenascin-C levels were measured in 130 controls and 130 severe TBI patients. Trauma severity was reflected by admission Glasgow Coma Scale (GCS) score and prognosis variables were 30-day mortality and 30-day overall survival. The statistical methods included bivariate test, multivariate analysis and receiver operating characteristics curve analysis. Results: As compared with the controls, serum tenascin-C levels were significantly elevated in the patients. Serum tenascin-C levels were independently correlated with GCS scores, were associated with 30-day mortality and 30-day overall survival as well as significantly predicted 30-day mortality. Conclusions: Elevated serum tenascin-C levels clearly reflect trauma severity and mortality following TBI. |
| Key words: Traumatic brain injury Tenascin-C Severity Mortality |