| 摘要: |
| 【摘要】 目的 探讨喉癌患者接受手术治疗后的远期疗效及相关影响因素。方法 选择128例喉癌患者的临床资料进行回顾性分析并随访其生存情况。采用Kaplan-Meier 法计算生存率；采用 Cox 比例风险模型对预后影响因素进行单因素及多因素分析。结果 128例患者失访4例，随访率为96.9%，1年、3年、5年生存率依次为96.1%、85.9%、75.0%。单因素分析发现，年龄、肿瘤原发部位、病理分级、肿瘤大小、T分级、N分级、临床分期、术式、颈淋巴结清扫及治疗方式与喉癌患者术后5年生存率有显著相关性（P＜0.01）。多因素分析发现喉癌患者手术预后的独立危险因素为年龄、病理分级及临床分期。结论 手术治疗喉癌的5年生存率较高；年龄、病理分级及临床分期是影响喉癌患者手术预后的独立危险因素。 |
| 关键词: 喉癌 手术治疗 生存率 影响因素 |
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| 基金项目:浙江省自然科学基金（No.LY14H160003），宁波市医疗卫生品牌学科建设项目资助：耳鼻咽喉头颈疾病诊疗中心（No。PPXK2018-02），浙江省医药卫生省部培育计划（No.2014PYA017），宁波市科技创新团队（No.2012B82019），宁波市重大择优委托项目（No.2012C5015），浙江省医药卫生科技计划项目（No.2012ZDA042; No.2018RC063） |
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| Long-term efficacy and influencing factors of surgical treatment for patients with laryngeal cancer |
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tongqiaoling1, shenzhisen1, yingyanyan2, denghongxia1
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1.Department of Otorhinolaryngology and Head and Neck Surgery, The Affiliated Lihuili Hospital, Medical School of Ningbo University;2.Ningbo Municipal Center For Disease Control and Prevention
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| Abstract: |
| 【Abstract】 Objective To explore the long-term efficacy and related influencing factors of patients with laryngeal cancer after surgery. Methods The clinical data of 128 patients with laryngeal cancer were selected for retrospective analysis and the survival of each enrolled patient was followed up. The survival rate was calculated using the Kaplan-Meier method. Prognostic factors were analyzed using the Cox proportional hazards model. Results The follow-up rate of 128 patients was 96.9%. The 1-, 3-, and 5-year survival rates were 96.1%, 85.9%, and 75.0%, respectively. The univariate analysis found that age, primary tumor location, pathological grade, tumor size, T grade, N grade, clinical stage, surgical procedure, cervical lymph node dissection and treatment were significantly associated with 5-year survival rate in patients with laryngeal cancer (P<0.01). The multivariate analysis found that the independent risk factors for surgical outcome in patients with laryngeal cancer were age, pathological grade and clinical stage. Conclusion The prognosis of laryngeal cancer patients with surgical treatment is related to many clinical factors. Age, pathological grade and clinical stage are independent risk factors for the prognosis of patients with laryngeal cancer. |
| Key words: Laryngeal cancer surgical treatment survival rate influencing factors |