TNFAIP3变异与自身免疫性疾病研究进展

汪晨; 吴际; 李秋彤; 蒋春明

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TNFAIP3变异与自身免疫性疾病研究进展
汪晨¹, 吴际¹, 李秋彤¹, 蒋春明²
1.浙江中医药大学第四临床医学院（杭州市第一人民医院）;2.西湖大学医学院附属杭州市第一人民医院儿科

摘要:

TNFAIP3编码的A20蛋白是一种重要的免疫负调节分子,其基因变异与类风湿关节炎、系统性红斑狼疮、干燥综合征、溃疡性结肠炎等多种自身免疫性疾病的发生和发展密切相关。目前,TNFAIP3在免疫系统中的作用及其变异的生物学机制仍未明确,治疗上的应用前景也未完全阐明。本文将对TNFAIP3变异与自身免疫性疾病的关联进行综述,并展望该领域未来的研究方向。

关键词: TNFAIP3 A20 自身免疫性疾病综述

DOI：

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基金项目:

Research Progress on TNFAIP3 Variants and Autoimmune Diseases

Wang Chen¹, Wu Ji¹, Li Qiutong¹, Jiang Chunming²

1.Zhejiang Chinese Medical University;2.Hangzhou First Peoples Hospital

Abstract:

The A20 protein encoded by TNFAIP3 is an important immune negative regulatory molecule, and its genetic variants are closely associated with the occurrence and development of various autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, Sj?gren"s syndrome, and ulcerative colitis. Currently, the biological mechanisms of TNFAIP3"s role in the immune system and its variants remain unclear, and the prospects for therapeutic applications are not fully elucidated. This article will review the association between TNFAIP3 variants and autoimmune diseases, and provide insights into future research directions in this field.

Key words: TNFAIP3 A20 Autoimmune Diseases Review