| 摘要: |
| 结直肠癌(Colorectal Cancer, CRC)作为全球范围内第三高发的癌症类型,在中国,结直肠癌的发病率不仅逐年攀升,且患者群体日益年轻化。尤为值得关注的是,约25-30%的结直肠癌患者会经历肝转移,这一并发症显著影响患者的临床症状及疾病预后。近年来,科学研究深入探索了肠道、肝脏及肿瘤自身微环境对结直肠癌肝转移的影响,揭示了一个复杂而动态的转移机制网络。对结直肠癌肝转移病因和发病机制的深入研究,不仅有助于我们理解这一疾病的本质,更为寻找有效的干预策略提供了可能。本文旨在阐述近年来关于结直肠癌肝转移的研究进展,以期为该领域的深入研究提供参考。 |
| 关键词: 结直肠癌 肝脏转移 肿瘤微环境 |
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| 基金项目:宁波市自然基金项目；宁波市医疗中心李惠利医院“惠利基金”；宁海县社会发展类科技项目 |
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| Research progress on the impact of changes in the microenvironment on liver metastasis of colorectal cancer |
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JiangPan1, Xufeng2
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1.Department of Medicine,Ningbo University;2.Ningbo Medical Center Li Huili Hospital
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| Abstract: |
| Colorectal cancer is the third most common type of cancer in the world. In China, the incidence of colorectal cancer is not only rising year by year, but also the patient group is becoming younger and younger. Of particular concern, about 25-30% of colorectal cancer patients experience liver metastases, a complication that significantly affects clinical symptoms and disease prognosis. In recent years, scientific research has deeply explored the effects of intestinal tract, liver and tumor microenvironment on liver metastasis of colorectal cancer, revealing a complex and dynamic metastasis mechanism network. The in-depth study on the etiology and pathogenesis of liver metastasis of colorectal cancer not only helps us to understand the nature of this disease, but also provides the possibility to find effective intervention strategies. This article aims to review the research progress of liver metastasis of colorectal cancer in recent years, in order to provide reference for further research in this field. |
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