| 摘要: |
| 心血管代谢疾病是严重威胁人类健康的疾病，具有较高的发病率和死亡率，寻找新的有效治疗靶点一直是心血管领域的研究热点。沉默信息调节因子1（Sirtuin-1，SIRT1）是一种依赖烟酰胺腺嘌呤二核苷酸（NAD+）的Ⅲ类去乙酰化酶，主要定位于细胞核内，但在细胞质、细胞膜和细胞骨架中亦有少量存在。SIRT1的主要功能包括通过去乙酰化作用调控组蛋白和非组蛋白，从而调节细胞存活、内质网应激、DNA损伤修复、染色质重塑、细胞凋亡、能量和代谢稳态、氧化应激等过程。激活SIRT1对心血管代谢疾病的保护作用已被广泛研究，其在改善心脏功能、减缓动脉粥样硬化进程、降低炎症反应等方面发挥着重要作用。因此，SIRT1的去乙酰化酶活性在心血管疾病中的作用，尤其是其在糖尿病、心脏缺血、心肌肥大等多种疾病中的潜在机制，为心血管疾病的诊断与治疗提供了新的理论依据和治疗靶点。本文综述了近年来关于SIRT1在心血管代谢疾病中作用的研究进展，并讨论了其作为治疗靶点的前景。 |
| 关键词: SIRT1 去乙酰化 心血管代谢疾病 糖尿病肾病 动脉粥样硬化 衰老 |
| DOI： |
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| 基金项目:毕节市科学技术局（毕科合〔2023〕22号），贵州省卫生健康委科学技术基金项目(gzwkj2025-543) |
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何丽1,2,3, Song Yan4,5,6, Ting Zeng7,5,8, Zhang Li9,2,8, Zhang Yanyan10
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1.Qianxi poepols'2.'3.s hospital;4.People&5.#39;6.s Hospital of Qianxi;7.Qianxi People&8.s Hospital;9.Qianxi People'10.Guizhou Medical University
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| Abstract: |
| Cardiovascular metabolic diseases are serious threats to human health with high morbidity and mortality, and the search for new effective therapeutic targets has been a hot research topic in the cardiovascular field. Silent information regulator 1 (sirtuin-1, SIRT1) is a class III nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that is predominantly located in the nucleus, but is also present at low levels in the cytoplasm, cytosol and cytoskeleton. The major functions of SIRT1 include the regulation of histones and non-histone proteins through deacetylation, thereby regulating cell survival, ER stress, DNA damage repair, chromatin remodelling, apoptosis, energy and metabolic homeostasis, and oxidative stress. The protective effects of activated SIRT1 against cardiovascular metabolic diseases have been extensively studied and it plays an important role in improving cardiac function, slowing the process of atherosclerosis and reducing inflammatory responses. Therefore, the role of the deacetylase activity of SIRT1 in cardiovascular diseases, especially its potential mechanism in a variety of diseases such as diabetes mellitus, cardiac ischaemia and cardiac hypertrophy, provides a new theoretical basis and therapeutic target for the diagnosis and treatment of cardiovascular diseases. In this article, we review the research progress on the role of SIRT1 in cardiovascular metabolic diseases in recent years and discuss its prospects as a therapeutic target. |
| Key words: SIRT1 Deacetylation Cardiovascular metabolic diseases Diabetes nephropathy Atherosclerosis Senescence |