| 摘要: |
| 目的 探究肠内营养(EN)联合生长抑素(SST)治疗重症肺炎(SP)病人的效果及对其免疫功能、肠道功能、血清炎症因子水平的影响。方法 选取本院收治的SP病人80例(2022年6月至2023年12月),随机将病人分为EN组(40例)和联用组(40例)。EN组病人采用EN治疗,联用组病人在EN组基础上,联合SST治疗,两组病人连续治疗14d。观察两组病人治疗后的临床疗效、临床指标、营养状况、免疫功能、肠道功能、炎症因子。结果 治疗后,联用组治疗后的临床总有效率为92.50%(37/40),显著高于EN组的75.00%(30/40)(P＜0.05)。联用组病人的咳痰消失时间、退热时间、住院时间、腹胀缓解时间、肠鸣音恢复时间、腹痛缓解时间显著低于EN组(P＜0.05)。两组病人前白蛋白(PAB)、白蛋白(ALB)、血红蛋白(Hb)、CD3+、CD4+、CD4+/CD8+水平较治疗前显著提高(P＜0.05),联用组显著高于EN组(P＜0.05)。两组病人白细胞介素IL-6(IL-6)、血清降钙素原(PCT)、C反应蛋白(CRP)较治疗前显著降低(P＜0.05),联用组显著低于EN组(P＜0.05)。结论 SST联合EN治疗SP,能够提高病人的临床效果,改善肠道功能、营养状况和临床指标,提高免疫功能,降低炎症反应。 |
| 关键词: 肠内营养 重症肺炎 生长抑素 免疫功能 肠道功能 |
| DOI： |
| 分类号:R459.3 |
| 基金项目:2021年浙江省医师协会临床研究基金项目（编号：YS2021-1-016） |
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| Effect of somatostatin combined with enteral nutrition in treating severe pneumonia patients and its impacts on their immune function, intestinal function, and serum inflammatory factor levels |
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HUANG Hang-dong1,2, LI Dan-yu1,2, ZHU Xiao-feng1,2
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1.Department of Intensive Care,Jinhua Municipal Central Hospital,Jinhua Zhejiang 321000;2.China
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| Abstract: |
| Objective The effect of nteral nutrition (EN) combined with somatostatin (SST)e in treating patients with severe pneumonia (SP) and its impacts on immune function, intestinal function and serum inflammatory factor levels. Methods A total of 80 SP patients (June 2022 to December 2023) were randomly separated into EN group (40 cases) and combined group (40 cases). The patients in the EN group were treated with EN, and the patients in the combined group were treated with SST on the basis of the EN group, and the two groups were treated continuously for 14 days. The clinical efficacy, clinical indicators, nutritional status, immune function, intestinal function, and inflammatory factors of the two groups were observed. Results After treatment, the total clinical effective rate of the combined group was 92.50% (37/40), which was greatly higher than that of the EN group, which was 75.00% (30/40) (P<0.05). The sputum disappearance time, fever reduction time, hospital stay time, abdominal distension relief time, bowel sound recovery time and abdominal pain relief time in the combined group were greatly lower than those in the EN group (P<0.05). The levels of prealbumin (PAB), albumin (ALB), hemoglobin (Hb), CD3+, CD4+, and CD4+/CD8+ in the two groups were greatly higher than those before treatment (P<0.05), and those in the combined group were greatly higher than those in the EN group (P<0.05). The levels of interleukin IL-6 (IL-6), serum procalcitonin (PCT) and C-reactive protein (CRP) in the two groups were greatly lower than those before treatment (P<0.05), and those in the combined group were greatly lower than those in the EN group (P<0.05). Conclusion: EN combined with SST treatment for SP can improve the clinical efficacy of patients, improve intestinal function, nutritional status, and clinical indicators, enhance immune function, and reduce inflammatory response. |
| Key words: Enteral nutrition Severe pneumonia Somatostatin Immune function Intestinal function |