| 摘要: |
| 目的 ：基于多模态磁共振评估夜间工作者脑白质异常信号，以探讨非正常生物钟时期工作是否导致更严重的白质损伤及可能的相关因素。
方法 ：本研究共招募出夜间工作出租车司机68名，以6:00与18:00点左右为交接班时间分为白班组（n=34）和夜班组（n=34）。收集多模态MRI数据包括高清结构像及DTI成像数据及临床资料，基于MRI结构像主观评估每个被试者脑白质高信号的Fazekas等级、数目和体积。基于体素分析两组白质体积之间有差异脑区，对有差异脑区筛选出DTI特征值并在夜班人群中依据高血压、高血脂及糖尿病进行亚组分析，以明确夜间工作者白质损伤的主要部位和高危因素。
结果：白班组和夜班组的白质高信号的数量、体积及全脑Fazekas评级均有统计学差异（p< 0.05）。脑白质体积减少的脑区中左侧颞中回的FA值、MD值、AD值和RD值在正常组和颠倒组之间均有统计学差异（p< 0.05），而右侧三角部额下回、右梭状回、右颞中回的DTI特征值在两组间均无统计学差异（p> 0.05）。夜班组人群中左颞中回脑区的FA在高血压亚组和高脂血症亚组中均有统计学差异（t=2.175，-2.738；p< 0.05），RD值在高血压亚组中也有统计学差异（t=-2.269；p< 0.05）。
结论 ：夜班人群相比非夜班人群具有更重的脑白质损伤，尤其是左颞中回，而高血压和高脂血症可能会加重夜班人群的白质损伤。 |
| 关键词: 脑白质损伤，夜班人群，磁共振，VBM、WMH |
| DOI： |
| 分类号: |
| 基金项目:DTI联合体素分析预测昼夜节律颠倒人群脑白质高信号的应用研究, |
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| Research on the Evaluation of White Matter Injury in Nighttime Workers Based on Multimodal MRI |
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Song Qiaowei1,2,3,4,2,3,5, Shu Zhenyu1,2,2,2,2,2,2,2,3,4,2,2,2,2,2,2,2,3,5, Peng Jiaxuan1,2,3,4,2,3,5, Hou Jie1,2,3,4,2,3,5
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1.Zhejiang Provincial People&2.amp;3.#39;4.&5.s Hospital
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| Abstract: |
| Objective: To evaluate the abnormal signals of white matter in nighttime workers based on multimodal magnetic resonance imaging, in order to explore whether working during abnormal biological clock periods leads to more severe white matter damage and possible related factors.
Method: This study recruited a total of 68 taxi drivers who worked at night. They were divided into white shift (n=34) and night shift (n=34) with shift handover times around 6:00 and 18:00. Collect multimodal MRI data, including high-definition structural images, DTI imaging data, and clinical data, and subjectively evaluate the Fazekas level, number, and volume of white matter hyperintensities in each subject based on MRI structural images. Based on the voxel analysis of the brain regions with different white matter volumes between the two groups, the DTI characteristic values of the different brain regions were screened out and subgroup analysis was carried out in the night shift population according to hypertension, hyperlipidemia and diabetes to identify the main parts and high-risk factors of white matter injury in night workers.
The results showed that there were statistically significant differences (p<0.05) in the quantity, volume, and whole brain Fazekas rating of white matter hyperintensities between the white team and the night team. The FA value, MD value, AD value, and RD value of the left temporal gyrus in the brain area with reduced white matter volume showed statistical differences between the normal group and the inverted group (p<0.05), while the DTI characteristic values of the right triangular inferior frontal gyrus, right fusiform gyrus, and right temporal gyrus showed no statistical differences between the two groups (p>0.05). The FA values in the left temporal gyrus of the night shift group showed statistical differences in both the hypertension and hyperlipidemia subgroups (t=2.175, -2.738; p<0.05), and the RD values also showed statistical differences in the hypertension subgroup (t=-2.269; p<0.05).
Conclusion: Night shift populations have more severe white matter damage compared to non night shift populations, especially in the left temporal gyrus, and hypertension and hyperlipidemia may exacerbate white matter damage in night shift populations. |
| Key words: White matter brain injury, night shift population, magnetic resonance imaging, VBM, WMH |