| 摘要: |
| 失巢凋亡是一种重要的程序性细胞死亡方式，是防止癌细胞转移的天然防御机制。而癌细胞通过激活促存活通路、经历上皮-间质转化过程（EMT）和改变整合素表达模式来逃避失巢凋亡，从而产生耐药性，导致肿瘤的转移。本文综述了失巢凋亡（Anoikis）在结直肠癌中的最新研究进展，包括探讨其分子机制、诱导失巢凋亡相关化合物、相关预后模型及药敏研究等，重点关注了结直肠癌失巢凋亡耐药性的相关研究。最后，本文还简要介绍了失巢凋亡在其他肿瘤中的最新研究进展。本综述旨在加深对失巢凋亡的理解，为未来治疗结直肠癌的相关研究提供新的思路和方向。 |
| 关键词: 失巢凋亡 结直肠癌 肿瘤 机制 |
| DOI： |
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| 基金项目:宁波市重点扶持学科 |
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| Research progress on anoikis in Colorectal cancer |
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linxi,cuiwei
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NINGBO MEDICAL CENTER LIHUILI HOSPITAL
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| Abstract: |
| Anoikis is an important form of programmed cell death and serves as a natural defense mechanism to prevent cancer cell metastasis. However, cancer cells can evade anoikis by activating pro-survival pathways, undergoing epithelial-mesenchymal transition (EMT), and altering integrin expression patterns, leading to drug resistance and tumor metastasis. This review summarizes the latest research progress on anoikis in colorectal cancer, focusing on its molecular mechanisms, compounds that induce anoikis, related prognostic models and drug sensitivity studies. Special emphasis is placed on the research related to anoikis resistance in colorectal cancer. Finally, the review briefly discusses the recent advancements in the study of anoikis in other cancers. This review aims to deepen the understanding of anoikis and provide new insights and directions for future research on colorectal cancer therapies. |
| Key words: Anoikis Colorectal cancer Tumor Mechanism |