| 摘要: |
| 乳腺癌患者罹患抑郁症的风险显著增高，其潜在病理机制尚未阐明。普通人群中炎症的中枢和外周来源都与抑郁症的发病机制有关。同时，乳腺癌本身亦可诱发炎症反应，而外周及中枢神经炎症可能在乳腺癌与抑郁症的双向关联中发挥中介作用。中枢炎症主要由中枢神经系统内活化的小胶质细胞、星形胶质细胞介导；外周炎症则主要涉及肠道神经系统、胃肠道微环境、外周实体瘤组织和T细胞信号传导。本综述重点介绍中枢和外周炎症在乳腺癌并发抑郁症中的关键调控作用。 |
| 关键词: 乳腺癌 抑郁症 神经炎症 外周炎症 |
| DOI： |
| 分类号: |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| The Role of Central and Peripheral Inflammation in the Comorbidity of Breast cancer and Depression. |
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Qinmoyi, Fanhongqiao
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The First Hospital of Hunan University of Chinese Medicine
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| Abstract: |
| The risk of developing depression increases in patients with breast cancer, and the underlying mechanisms remain unclear.Both central and peripheral sources of inflammation are associated with the pathogenesis of depression. Meanwhile, breast cancer can also lead to inflammation, and peripheral and central nervous system inflammation may play a mediating role in the bidirectional relationship between breast cancer and depression. Central inflammation is mainly composed of activated microglia and astrocytes within the central nervous system; peripheral inflammation mainly refers to the enteric nervous system, the gastrointestinal tract, peripheral solid tumor tissues, and T-cell signaling. This review highlights the important roles played by central and peripheral inflammation in the comorbidity of breast cancer and depression. |
| Key words: Breast cancer Depression Neuroinflammation Peripheral inflammation |