| 摘要: |
| 目的：探讨全身免疫炎症指数（SII）、可溶性白细胞介素-2受体（sIL-2R）和C反应蛋白/白蛋白比值（CRP/ALB）在急性胰腺炎（AP）患者中的变化及其与疾病严重程度的相关性。方法：选择金华市中医医院于2021年12月~2024年12月收治的AP患者376例，根据病情严重程度分为MAP组和SAP组。记录患者入院时BISAP评分和Ranson评分。采用血细胞分析仪测定白细胞计数、血小板、中性粒细胞、淋巴细胞计数，计算SII。运用ELISA法测定血清sIL-2R、CRP和ALB水平，计算CRP/ALB比值。比较两组BISAP评分和Ranson评分，SII、sIL-2R和CRP/ALB变化；采用Pearson相关分析SII、sIL-2R和CRP/ALB与BISAP评分和Ranson评分相关性；采用多因素Logistic回归分析影响AP患者病情严重程度危险因素。结果：SAP组BISAP评分和Ranson评分高于MAP组（P<0.05）。SAP组SII、sIL-2R和CRP/ALB高于MAP组（P<0.05）。经Pearson相关分析显示，SII、sIL-2R和CRP/ALB与BISAP评分呈正相关（P<0.05）；且SII、sIL-2R和CRP/ALB与Ranson评分呈正相关（P<0.05）。SII、sIL-2R和CRP/ALB是AP患者病情严重程度的独立危险因素（P<0.05）。结论：SII、sIL-2R和CRP/ALB在SAP患者中显著升高，且与疾病严重程度密切相关，可作为评估AP严重程度的潜在生物标志物，具有早期预警价值，值得临床借鉴。 |
| 关键词: 全身免疫炎症指数 可溶性白细胞介素-2 受体 C反应蛋白/白蛋白比值 急性胰腺炎 病情严重程度 |
| DOI： |
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| Correlation analysis between changes in systemic immune inflammatory index, sIL-2R, CRP/ALB and severity of acute pancreatitis |
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Fu Jinlong, Yao Jingzi, Huang Jian
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Jinhua Traditional Chinese Medicine Hospital
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| Abstract: |
| Objective: To investigate the changes of systemic immune inflammation index (SII), soluble interleukin-2 receptor (sIL-2R), and C-reactive protein/albumin ratio (CRP/ALB) in patients with acute pancreatitis (AP) and their correlation with disease severity. Method: 376 patients with AP admitted to Jinhua Traditional Chinese Medicine Hospital from December 2021 to December 2024 divided into MAP group and SAP group according to the severity of condition. Record the bedside severity index (BISAP) score and Ranson score of the patient upon admission. Use a blood cell analyzer to measure white blood cell count, platelet count, neutrophil count, lymphocyte count, and calculate SII. Use ELISA to measure serum levels of sIL-2R, CRP, and ALB, and calculate the CRP/ALB ratio. Compare the BISAP score and Ranson score, SII, sIL-2R, and CRP/ALB changes between two groups; Pearson correlation analysis was used to investigate the correlation between SII, sIL-2R, CRP/ALB and BISAP score and Ranson score; Logistic regression analysis was used to investigate the relationship between SII, sIL-2R, CRP/ALB and the severity of AP patients. Result: The SAP group BISAP and Ranson scores were higher than MAP group (P<0.05). The SAP group levels of SII, sIL-2R, and CRP/ALB were higher than MAP group (P<0.05). Pearson correlation analysis showed that SII, sIL-2R, CRP/ALB were positively correlated with BISAP score (P<0.05); SII, sIL-2R, CRP/ALB were positively correlated with Ranson score (P<0.05). The results of multiple logistic regression analysis showed that SII, sIL-2R, and CRP/ALB were independent risk factors for the severity of AP patients (P<0.05). Conclusion: SII, sIL-2R, and CRP/ALB are significantly elevated in SAP patients and closely related to disease severity, which can serve as potential biomarkers for assessing the severity of AP, it has early warning value and is worth clinical reference. |
| Key words: Systemic immune inflammation index Soluble interleukin-2 receptor C-reactive protein/albumin ratio Acute pancreatitis Severity of illness |