| 摘要: |
| 【摘要】目的 本研究旨在通过职业分层，系统评估浙江省以及周边省份民众对肠道菌群移植（Fecal Microbiota Transplantation, FMT）技术的认知水平、接受度及其群体差异性，重点解析医疗/非医疗背景对认知差异的独立影响，为优化FMT技术的临床转化路径提供循证依据。方法 采用横断面研究设计，依托网络平台构建结构化问卷，覆盖医务工作者（含消化内科、肝病内科等专科人员）及非医务群体。通过分层抽样获取有效样本，应用SPSS26.0进行描述性统计、卡方检验及多元Logistic回归分析，量化职业类别、教育水平等变量对FMT认知的关联强度。结果 本研究共纳入有效样本875?例，其中女性533?例（60.91?%），医务工作者群体占比49.83?%（436?例），研究生及以上学历占比24?%（210?例）。调查显示，26.03?%的受访者对菌群移植技术缺乏基础认知，40.75?%的受访者对其治疗流程完全未知。在适应证认知层面，公众普遍认为FMT在胃肠道疾病中的应用价值，且医务工作者对适应证的掌握显著优于非医务工作者（χ2?=?12.37，P?
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| 关键词: 肠道菌群移植 问卷调查 健康教育 |
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| 基金项目:国家重点研发计划“病原学与防疫技术体系研究”；国家重点研发计划生物大分子与微生物组重点专项 |
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| Study on Public Perception Disparities and Influencing Factors of Fecal Microbiota Transplantation (FMT) Based on Occupational Stratification |
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Xu Ying1, Ni Shuai2, Zhang Junjie1, Li Ye1, Luo Chaozhong1, Lin Meile3, Zou Pengfei1, Li Nan1, Gao Hainv4
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1.Department of Infectious Diseases, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University, Shulan International Medical College, Hangzhou;2.State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.;3.Graduate School, Zhejiang Chinese Medical University;4.Department of Infectious Diseases, Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province，Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University, Shulan International Medical College, Hangzhou
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| Abstract: |
| 【Abstract】Objective This study aimed to systematically assess public awareness, acceptance, and group differences regarding fecal microbiota transplantation (FMT) in Zhejiang Province and neighboring regions through occupational stratification. Particular emphasis was placed on evaluating the independent impact of medical versus non-medical backgrounds on cognitive disparities, so as to provide evidence for optimizing the clinical translation pathway of FMT. Methods A cross-sectional study design was adopted. A structured questionnaire was developed and distributed via online platforms to both medical workers (including specialists from departments of gastroenterology and hepatology) and non-medical populations. Valid samples were obtained using stratified sampling. Descriptive statistics, chi-square tests, and multivariable logistic regression analyses were performed using SPSS 26.0 to quantify the associations between occupational category, educational level, and FMT-related awareness and acceptance. Results A total of 875 valid questionnaires were included, of which 533 respondents were female (60.91 %). Medical workers accounted for 49.83 % (n = 436) of the sample, and participants with a postgraduate degree or above accounted for 24 % (n = 210). Overall, 26.03 % of respondents lacked basic knowledge of FMT, and 40.75 % were completely unfamiliar with its treatment process. With regard to awareness of indications, the public generally recognized the application value of FMT in gastrointestinal diseases, and medical workers demonstrated significantly better knowledge of indications than non-medical respondents (χ2 = 12.37, P < 0.001). Multivariable logistic regression analysis showed that male gender (OR = 1.508, 95 % CI 1.081–2.103, P = 0.015), possession of basic FMT knowledge (OR = 2.564, 95 % CI 1.845–3.563, P < 0.001), and recognition of the low-risk and high-efficacy characteristics of FMT (OR = 1.641, 95 % CI 1.433–2.264, P < 0.001) were independent positive predictors of treatment acceptance. The overall acceptance rate was 64.04 %. Occupational identity was not an independent influencing factor for acceptance (P = 0.214). Donor safety was identified as a common concern across occupational groups, with concern rates of 82.1 % among medical workers and 76.8 % among non-medical workers. Among respondents who completely rejected traditional FMT, 28.57 % expressed an open attitude toward capsulated fecal microbiota transplantation (cFMT), and 14.29 % explicitly indicated willingness to accept this approach. Conclusion Public awareness of FMT in Zhejiang Province and neighboring regions exhibits significant occupational stratification, with higher knowledge levels among medical workers; however, occupational identity does not independently influence treatment acceptance. Donor safety remains the primary public concern. As a modified intervention approach, cFMT may improve acceptance among potential candidate populations and warrants further investigation. |
| Key words: Fecal microbiota transplantation (FMT) Surveys and Questionnaires Health Education |