| 摘要: |
| 目的 探讨10例女性生殖系统弥漫大B细胞淋巴瘤（diffuse large B-cell lymphoma ，DLBCL）的临床及病理特征。方法 收集10例女性生殖系统DLBCL患者的年龄、临床症状、影像学、血清学检查、病理特征、治疗及预后等信息。结果 10例DLBCL患者中位年龄65.5岁（45-75岁），临床表现以妇科相关症状多见；病变部位多累及子宫、宫颈、内膜、卵巢及输卵管。组织学形态：肿瘤细胞形态多样，体积增大，可见突出的核仁、粗糙的染色质，核分裂像易见；免疫组织化学表达：肿瘤细胞对CD20均呈弥漫性阳性，大部分病例不表达CD3，肿瘤具有较高的增殖指数（Ki67指数）。治疗及预后：治疗上以手术联合化疗为主；在随访中，无瘤生存6例，复发2例，骨转移1例，死亡1例。结论 女性生殖系统DLBCL较为少见，患者的临床表现和影像学检查往往缺乏特异性，提高临床医师对DLBCL的认识，借助病理活检，有助于患者获得更有效的治疗。 |
| 关键词: 女性生殖系统 弥漫大B细胞淋巴瘤 临床病理特征 治疗及预后 |
| DOI： |
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| 基金项目:浙江省自然科学基金（LQ22H040008）;温州市科研项目（Y2023509） |
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| Clinicopathologic characteristics of diffuse large B-cell lymphoma in the female reproductive system：analysis of 10 cases |
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Xu Feifei1, Chen Wanwan1, MiaoChengfeng2, Zhao zhiguang1, YI Baozhu3, LI Huitao3
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1.The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang;2.The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang;3.The Seconed Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang
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| Abstract: |
| Abstract
Objective To summarize the clinical manifestations and pathological characteristics of 10 cases of diffuse large B-cell lymphoma (DLBCL) in the female reproductive system. Methods Collect data from 10 patients diagnosed with DLBCL in the female reproductive system, including age, clinical symptoms, imaging, serological examination, pathological features, treatment methods and prognostic information. Results The median age of 10 DLBCL patients was 65.5 years (45-75 years), with gynecological related symptoms being more common in clinical manifestations. The affected areas often involved the uterus, cervix, endometrium, ovaries, and fallopian tubes. Histologically: Tumor cells had diverse morphologies and enlarged cell size, with prominent nucleoli and rough chromatin. Nuclear division was easily visible. Immunohistochemically: Tumor cells were positive for CD20, and most of cases were negative for CD3，with a high proliferation index (Ki67 index). Surgery combined with chemotherapy was the main treatment; during the follow-up, 6 cases achieved event free survival after chemotherapy and surgery, 2 cases recurred, 1 case had undergone bone metastasis, and 1 case died. Conclusion DLBCL in the female reproductive system is relatively rare, due to the lack of specificity of clinical manifestations and imaging examinations. Improving clinical physicians' understanding of DLBCL and using pathological biopsy can help patients obtain more effective treatment. |
| Key words: Female reproductive system Diffuse large B-cell lymphoma Clinical and pathological feature Treatment and prognosis |