| 摘要: |
| 目的 观察并比较透明质酸钠、碱化利多卡因联合肝素膀胱灌注治疗膀胱疼痛综合征/ 间质性膀胱炎（BPS/IC）的临
床疗效。方法 将63 例BPS/IC 患者按随机单盲的原则分成A、B 两组，A 组32 例，B 组31 例。A 组患者予膀胱灌注透明质酸钠40ml；B 组予膀胱灌注碱化利多卡因联合肝素治疗，即用5%碳酸氢钠10ml、2%利多卡因10ml、肝素钠2.5 万U 和0.9%氯化钠15ml的混合液行膀胱灌注。两组均保留40~60min，每周2 次，4周后改为每周1 次，共16 次。观察两组患者用药前及用药开始后4、12周时的O’Leary-Sant平均症状评分（ICPI）、问题评分（ICSI）及生活质量评分（QOL），并记录不良反应。结果 两组患者治疗开始后4周和12 周ICPI、ICSI 及QOL评分均有明显改善，与治疗前比较均有统计学差异（均P＜0.05）。治疗4 周后两组的ICPI、ICSI 及QOL 评分下降分值比较均无统计学差异（均P＞0.05），但治疗12 周后A 组的ICPI、ICSI 及QOL评分下降分值较B 组更为明显（均P＜0.05）。所有患者治疗过程中均未发生明显不良反应。结论 透明质酸钠及碱化利多卡因联合肝素膀胱灌注均能改善BPS/IC患者的临床症状，而透明质酸钠疗效更为显著。 |
| 关键词: 膀胱疼痛综合征/间质性膀胱炎 肝素 利多卡因 透明质酸钠 |
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| Efficacy of intravesical instillation of sodium hyaluronate or heparin with alkalinized lidocaine for bladder pain syndrome/interstitial cystitis |
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CAI Jiangyi,SHAO Shaofeng,CHENG Bin,XIE Hui
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the First Affiliated Hospital of Wenzhou Medical University
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| Abstract: |
| Objective To compare the efficacy of intravesical instillation of sodium hyaluronate and heparin with alkalinized lidocaine for bladder pain syndrome/interstitial cystitis (BPS/IC). Methods Sixty three patients with BPS/IC were randomly assigned into two groups: patients in group A (n=32) were treated with intravesical instilation of sodium hyaluronate 40ml and patients in group B(n=31) were treated with intravesical instillation of alkalinized 2%lidocaine 10 ml with heparin 25 000U. The
drug instillation lasted for 40~60 min, twice a week for 4 weeks, followed by once a week for 12 weeks. The pre- and post-treatment assessments were conducted with O'Leary-Sant IC symptom(ICSI) and problemindex(ICPI), and quality of life score(QOL).Adverse events were recorded. Results After treatment for 4 and 10 weeks, ICSI, ICPI and QOL scores in both groups were significantly
improved compared to those before treatment (P＜0.05). There was no significant difference in improving degrees after 4weeks of treatment between two groups (P＞0.05), however, the improvement in group A was more marked than that in group B after 10 weeks of treatment (P＜0.05). Conclusion Intravesical instillation of sodiumhyaluronate and heparin with alkalinized lidocaine are both effective in treatment of BPS/IC, and the efficacy of sodiumhyaluronate may be more significant. |
| Key words: Bladder pain syndrome/interstitial cystitis Heparin Lidocaine Sodiumhyaluronate |
