| 摘要: |
| 目的 探讨脑外伤患者血浆脂联素水平的变化规律及与脑外伤严重度的相关性。方法 选取86例重型脑外伤患者
和86例健康体检者，分别于入院时、入院后第1、2、3、5、7天和体检时清晨空腹抽取静脉血，ELISA 法测定血浆脂联素水平。结果 脑外伤后血浆脂联素水平6h内升高，24h到达高峰，后逐渐下降，入院时、入院后第1、2、3、5、7天的血浆脂联素水平均明显高于健康对照组（均P＜0.01）；蛛网膜下腔出血、环池消失、中线移位（＞5mm）和瞳孔散大患者各个时间点血浆脂联素水平显著高于其对照组（均P＜0.01）。入院时格拉斯哥昏迷评分与各个时间点血浆脂联素水平均呈负相关（均P＜0.01）。结论 脑外伤后血浆脂联素水平升高，与脑外伤严重度显著相关。 |
| 关键词: 脂联素,脑外伤,严重度 |
| DOI： |
| 分类号: |
| 基金项目:绍兴市科技计划项目 |
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| Plasma adiponectin levels in patients with traumatic brain injury and its clinical significance |
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SHEN Liangjun, YANG Songbin, LV Qingwei, ZHANG Guohai, ZHOU Jing, GUO Mi, HUANG Hangbin, LI Zhao, YANG Chunsong
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Shenzhou People's Hospital
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| Abstract: |
| Objective To investigate plasma adiponectin levels in patients with traumatic brain injury (TBI) and its clinical significance. Methods Plasma adiponectin levels were measured by enzyme-linked immunosorbent assay (ELISA) in 86 patients with severe brain injury on admission and at d1, d2, d3, d5, d7 after admission. Adiponectin levels were also measured in 86 subjects on health checkup as controls. Results After TBI, plasma adiponectin levels were elevated within 6h,peaked at 24h and decreased gradually thereafter. Plasma adiponectin levels at all time points after TBI were significantly higher than that in healthy controls (all P＜0.01). Glasgow coma scale scores at admission were negatively correlated with plasma adiponectin levels at each time point after TBI (all P＜0.01). Patients with midline shift (＞5mm), disappearance of cisterna ambiens,presence of subarachnoid hemorrhage or dilation of pupil had higher plasma adiponectin levels at each time point after TBI(all P＜0.01). Conclusion Plasma adiponectin levels are elevated after TBI, and its levels are highly associated with the severityof brain trauma. |
| Key words: Adiponectin Traumatic brain injury Severity |
