| 摘要: |
| 目的检测人体胃癌组织中B7-H1的表达，探讨其与患者临床病理特征的关系及对预后的影响。方法采用免疫组化染色法检测胃癌组织中B7-H1的表达，分析其在胃癌组织中的阳性表达率与患者临床病理特征之间的关系，并绘制患者术后生存曲线，评价B7-H1表达对预后的影响。结果65例胃癌组织中癌细胞的细胞膜、细胞质以及部分肿瘤组织浸润的淋巴管及淋巴细胞中均有检测到B7-H1的阳性表达，阳性率为36.9%。有淋巴结转移或脉管内有癌栓的患者B7-H1阳性率较高（均P＜0.05）。B7-H1阳性表达的胃癌患者术后5年生存率（25.0%）低于阴性表达的患者（56.1%）（P＜0.05）。结论B7-H1阳性表达的胃癌患者易发生淋巴结转移，预后较差，B7-H1可作为评价胃癌患者预后的指标之一。 |
| 关键词: B7-H1 蛋白 胃癌 临床病理特征 预后 |
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| Expression of B7-H1 protein in gastric cancer and its clinical significance |
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WANG Zhanwei, Han Hui, Han Shaoliang
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the First Affiliated Hospital of Wenzhou Medical University
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| Abstract: |
| Objective To investigate the expression of B7-H1 in gastric carcinoma and its clinicopathological significance. Methods Immunohistochemical staining was used to detect the expression of B7-H1 protein in gastric cancer. The relationship between the B7-H1 protein expression and clinicopathological parameters was analyzed. Results Immunohistochemical staining revealed that B7-H1 was expressed on membrane, cytoplasm of cancer cells and tumor infiltrating lymphocytes. B7-H1 protein in gastric cancer was correlated with lymph node metastasis and vessel infiltration (P＜0.05). The postoperative 5-year survival rate of patients with negative B7-H1 expression (25.0% ) was lower than that of those with positive B7-H1 expression (56.1%, P＜0.05). Conclusion Gastric cancer patients with B7-H1 positive expression are likely to have lymph node metastasis and poor prognosis, indicating that it might be used as an indicator of prognosis for gastric cancer patients. |
| Key words: B7-H1 protein Gastric cancer Clinicopathologic feature Prognosis |
