| 摘要: |
| 目的 研究血清癌胚抗原（CEA）在系统性疾病相关的间质性肺病（ILD）患者中的表达情况，及其与疾病严重程度及
预后的相关性。方法 收集80 例系统性疾病相关ILD 患者，并设立对照组，统计血清CEA 水平，并将血清CEA 水平与疾病严重程度指标进行Pearson相关分析，最后采用Kaplan-Meier生存分析及Cox 回归分析评估血清CEA 水平对1 年生存率的影响。结果 病例组血清CEA 水平明显升高，血清CEA 水平与ILD 严重程度指标均相关，并与1年生存率显著相关（均P＜0.05）。结论 血清CEA 水平是评估系统性疾病相关ILD 病情及预后有较好相关性的血清学指标。 |
| 关键词: 癌胚抗原 间质性肺病 结缔组织病 预后 |
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| Correlation of serum CEA levels with severity and survival of systemic disease-related interstitial lung disease (ILD) |
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JIN Qian, XU Xianrong, ZHENG Jisheng, ZHOU Ying, CHAI Xiujuan, HUANG Feihua
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Tongde Hospital of Zhejiag Province
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| Abstract: |
| Objective To investigate the correlation of serum carcinoembryonic antigen (CEA) levels with the severity and survival of systematic disease-related interstitial lung disease (ILD). Methods Serum CEA levels were measured by microparticle enzyme immunoassays (Abbott kits and AxSYM system in 80 patients with ILD and 80 healthy subjects. Correlation of serum CEA levels with pulmonary function (DLco % and FVC% and OI) was evaluated by Pearson's correlation; that with fibrosis score on HRCT was analyzed by Spearman's correlation. Survival curve of patients was generated using Kaplan-Meier method,equality of survival distributions was tested using log-rank testing, univariate and multivariate Cox regression analyses. Results SerumCEA levels were higher in ILD patients than those in controls(P＜0.05), were correlated with DLco%, FVC%, OI and fibrosis score on HRCT(P＜0.05). SerumCEA levels were negatively correlated with 1-y survival of patients(P＜0.05). Univariate and multivariate Cox regression analysis demonstrated that serum CEA was an independent predictor of survival (HR=1.847, P=0.000).Conclusion Serum CEA can be a cost-effective and convenient marker to evaluate disease severity, survival and prognosis of patients with systemic disease-related ILD. |
| Key words: Carcinoembryonic antigen Interstitial lung disease Connective tissue disease Prognosis |
