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| 以胶原蛋白为基质的肠内营养制剂应用效果多中心临床研究 |
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陈秋霞1, 王蕾蕾2, 叶丽佳2, 何芳2, 张片红2, 戴福仁3, 魏琳4, 毛春英5, 徐斌斌6
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1.衢州市柯城区人民医院营养科;2.浙江大学医学院附属第二医院营养科;3.温州医科大学附属第三医院营养科;4.丽水市中心医院营养科;5.衢州市人民医院营养科;6.宁波市第二医院营养科
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| 摘要: |
| 目的通过多中心随机对照的临床试验研究，比较以胶原蛋白为基质的新型肠内营养制剂与标准型肠内营养制剂对患者营养状况的影响，以了解新型肠内营养制剂的临床应用效果。方法本研究共6家医疗单位共同参与，共收集91例，分为对照组（标准肠内营养）及干预组（以胶原蛋白为基质的肠内营养），管饲补充104.6~125.5kJ（25~30kcal）/（kg·d），共7d，检测研究开始前后患者体格指标、营养相关指标、安全性指标等。结果组内比较显示两组患者在管饲两种不同的肠内营养制剂后营养风险筛查评分（NRS2002）较管饲前均有所降低（均P＜0.025）；组间差值比较显示患者营养状况、营养风险筛查（NRS2002）评分、胃肠道不良反应在两组间均无统计学差异（均P＞0.025）。结论以胶原蛋白为基础经氨基酸模式优化后的肠内营养制剂与标准型肠内营养制剂均可以有效改善患者的营养状况，有助于促进患者的疾病预后。 |
| 关键词: 胶原蛋白 肠内营养制剂 血白蛋白 |
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| 基金项目:浙江省重大科技专项重点农业项目 |
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| Efficacy of collagen-based enteral nutrition: a multi-center clinical trial |
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Chen Qiuxia,Wang Leilei,Ye Lijia,He Fang,Zhang Pianhong,Dai Furen,Wei Lin,Mao Chunying,Xu Bingbing
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Kecheng District People's Hospital
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| Abstract: |
| Objective To investigate the effect of collagen-based enteral nutrition on nutritional status of patients. Methods Ninety one patients from 6 institutions were randomly assigned to receive standard enteral nutrition or collagen-based enteral nutrition with a dose of 104.6~125.5kJ(25~30kcal)/kg.d. The medical indicators, laboratory examination and gastroin- testinal reaction were documented in two groups before and after study. Results NRS2002 scores were significantly decreased after using EN in two groups (P＜0.025). There were no significant differences in nutritional status, medical indicators, NRS2002 scores, laboratory examination and gastrointestinal reaction between two groups. Conclusion Both collagen-based enteral nutrition and standard enteral nutrition preparations can improve the nutritional status of patients. |
| Key words: Collagen protein Enteral nutrition Albumin |