| 摘要: |
| 目的探讨血清胆红素水平与高尿酸血症的关系，进一步认识高尿酸血症患者的临床特点。方法回顾性分析参加体检的4812例研究对象的临床资料，分析血清胆红素水平与高尿酸血症的相关关系。结果高尿酸血症患者组血清总胆红素（TBil）水平显著高于正常对照组[13.0（10.0~16.0）μmol/Lvs12.0（9.0~15.0）μmol/L，P＜0.05]，且随着血清TBil水平升高，高尿酸血症患病率逐渐上升；相关性分析发现血清TBil水平与BMI、腰围、LDL-C、空腹血糖、肌酐均呈正相关（均P＜0.05）；进一步多因素logistic回归分析发现，血清TBil水平是高尿酸血症的患病危险因素[OR（95%CI）=1.021（1.007~1.034），P＜0.05]。结论血清胆红素水平变化与高尿酸血症存在密切联系，高尿酸血症患者血清胆红素水平显著升高。 |
| 关键词: 胆红素 高尿酸血症 相关关系 |
| DOI： |
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| 基金项目:国家自然科学基金资助项目；浙江省医药卫生科技计划项目 |
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| Association between serum bilirubin levels and hyperuricemia |
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WANG Zejun, FAN Xiuqin, WANG Weiwei, DONG Min, XIA Lulu, HONG Caijuan, XU Chengfu, YU Zhaohui, LI Youming
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the Fifth Yuhang District People's Hospital
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| Abstract: |
| Objective To investigate the association between serum bilirubin levels and hyperuricemia. Methods The data of 4812 adults attending annual health check were retrospectively analyzed. Results Subjects with hyperuricemia had higher serum total bilirubin levels then those without hyperuricemia [13.0 (10.0~16.0)vs.12.0 (9.0~15.0)μmol/L, P＜0.05]. Serum total bilirubin levels were positively associated with hyperuricemia. Spearman correlation analysis showed that serum bilirubin levels were positively correlated with body mass index, waist circumference, LDL-C, fasting blood glucose and creatinine (all P＜ 0.05). Multiple logistic regression analysis showed that the serum total bilirubin levels was an independently risk factor of hyperuricemia [OR (95%CI)=1.021 (1.007~1.034), P＜0.05]. Conclusion This study indicated that the serum bilirubin level was significantly associated with hyperuciemia. |
| Key words: Serum bilirubin Hyperuricemia Association |
