| 摘要: |
| 目的探讨帕罗西汀治疗躯体化障碍患者的疗效及神经电生理指标的变化。方法按序贯法对138例患者进行帕罗西汀20～50mg/d治疗8周，以90项症状清单（SCL-90）躯体化因子分、焦虑自评量表（SAS）和抑郁自评量表（SDS）作为心理学评估指标，以交感神经皮肤反应（SSR）中起始潜伏期和波幅作为神经电生理学指标来对照比较疗效及电生理学指标的变化。结果研究组总有效率为84.80%，治疗8周末的SLC-90躯体化因子分、SAS和SDS评分较治疗前明显下降（P＜0.05或0.01）；与对照组比较，治疗前研究组起始潜伏期明显延长（P＜0.01），波幅明显降低（P＜0.05）；治疗后研究组起始潜伏期及波幅无统计学差异（P＞0.05）。结论躯体化障碍存在神经电生理学指标的改变，帕罗西汀治疗能有效改善抑郁症状，恢复神经电生理学指标。 |
| 关键词: 躯体化障碍 帕罗西汀 神经电生理 |
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| 基金项目:台州市科技局资助项目 |
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| Efficacy of paroxitine for patients with somatization disorder and corresponding changes of neuro-electrophysiology |
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CHEN Wenze,CHEN Xuefen,ZHANG Junqing,JIANG Yibin
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Taizhou enze Medical Center
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| Abstract: |
| Objective To investigates the therapeutic efficacy of paroxitine for somatization disorder and corresponding changes on neuroelectrophysiology. Methods One hundred and thirty eight patients with somatization disorder were treated with paroxetine (mean dose 29.78 ±7.99mg/d) for 8 weeks using sequential approach. The Symptom Checklist 90 (SGL-90), Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS) were used to assay the therapeutic efficacy. The onset latency and amplitude of sympathetic skin reflex(SSR) was also measured before and after treatment. Results The efficacy rates of paroxetine on somatization disorder according to the somatic score of SCL-90 was 84.80% at wk 8. The somatic scores, SAS and SDS scores were all significantly decreased after 8-wk treatment(P＜0.05 or 0.01 ). The onset latency of the study group was significantly longer than that of group (P＜0.01), while the amplitude was significantly lower (P ＞0.05) before treatment; while after treatment there was no significant difference between two groups(P＜0.05). Conclusion Paroxetine is effective for somatic disor- der, leading to the improvement of symptoms and changes of neuro-electrophysiology of patients. |
| Key words: Somatization disorder Paroxetine Neuro-electrophysiology |
