| 摘要: |
| 目的采用任务转换范式探究情感性精神病患者认知灵活性的差异。方法对31例躁狂患者、30例抑郁患者及29例性别构成、年龄及受教育年限相匹配的正常对照组进行数字广度和言语流畅性等神经心理学背景测试，再对所有被试使用任务转换之线索提示范式进行测试。比较躁狂组、抑郁组与正常对照组的转换代价、混合代价。结果3组被试数字广度和言语流畅性测查结果差异有统计学意义（P＜0.01）；3组转换代价差异有统计学意义（P＜0.05），对照组小于躁狂组、抑郁组（均P＜0.05），躁狂组和抑郁组差异无统计学意义（P＞0.05）；3组混合代价差异无统计学意义（P＞0.05）；躁狂组、抑郁组的受教育年数、病程与神经心理学背景测试得分有相关性，额叶言语流畅性与转换任务反应时有显著相关（P＜0.05或0.01）。结论情感性精神病转换代价明显高于正常对照组，认知灵活性存在问题。 |
| 关键词: 躁狂发作 抑郁发作 任务转换 认知灵活性 |
| DOI： |
| 分类号: |
| 基金项目:杭州市卫生科技计划（重点）项目 |
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| Task switching in patients with affective psychosis |
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LIANG Yan, WANG Yongguang, WANG Yiquan, CHEN Zhiyu
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Hangzhou Seventh People's Hospital
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| Abstract: |
| Objective To assess the cognitive flexibility difference in psychiatric patients with manic episode and depressive episode with task-switch paradigm. Methods Thirty bipolar Ⅰ or bipolar Ⅱ patients without psychotic symptoms (manic group), 30 depression patients without psychotic symptoms (depression group) and 29 age and sex-matched healthy subjects (control group) were recruited in the study. Digit Symbol Test (DST) and Verbal Fluency Test (VFT) were carried out and the ability of task switching was evaluated with task cueing paradigm in all subjects. Results In DST and VFT tasks, the results had significant differences among three groups (P＜0.01). On odd-even and big-small tasks, the switch cost had significant differences among three groups (P＜0.05), the control group was less than manic (P＜0.05) and depressive group (P＜0.05), but there was not difference between manic group and depressive group(P ＞0.05). The years of education and the course of disease were associated with neuropsychological test scores. The frontal verbal fluency was significantly associated with switching time (P＜0.05 or P＜0.01). Conclusion The results suggest that there are problems of cognitive flexibility in affective psychosis pa- tients. |
| Key words: Manic Depression Task switch Cognitive Flexibility |
